Mouse Monoclonal GAG antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC-Fr and reacts with Feline immunodeficiency virus samples.
pH: 7.2
Preservative: 0.05% Sodium azide
Constituents: PBS
| Flow Cyt | ELISA | WB | ICC/IF | IHC-Fr | |
|---|---|---|---|---|---|
| Feline immunodeficiency virus | Expected | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Feline immunodeficiency virus | Dilution info - | Notes ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| Species | Dilution info | Notes |
|---|---|---|
Species Feline immunodeficiency virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Feline immunodeficiency virus | Dilution info - | Notes Detects a dominant WB bands of approximately 24kDa, and also detects p24 gag precursor bands at 36, 39, 49 and 52kDa under reducing conditions in Western blotting. |
| Species | Dilution info | Notes |
|---|---|---|
Species Feline immunodeficiency virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Feline immunodeficiency virus | Dilution info Use at an assay dependent concentration. | Notes - |
Capsid protein p24, FIV capsid protein p24, Feline immunodeficiency virus, Feline immunodeficiency virus capsid protein p24
Mouse Monoclonal GAG antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC-Fr and reacts with Feline immunodeficiency virus samples.
pH: 7.2
Preservative: 0.05% Sodium azide
Constituents: PBS
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The Feline Immunodeficiency Virus (FIV) p24 protein also known as the FIV capsid protein plays a mechanical role in the assembly and stability of the viral core. It has a molecular mass of approximately 24 kDa. This protein is expressed within infected feline cells where it forms the central part of the viral capsid a structure that encapsulates the viral RNA genome and associated proteins. The proper formation of the capsid is essential for the viral particle's integrity and its ability to successfully infect host cells.
The FIV p24 protein functions as a critical component of the viral capsid complex. It facilitates the encapsidation of the viral genome and interacts with other viral proteins such as reverse transcriptase and integrase during the viral life cycle. The p24 protein aids in the transport of retroviral complexes to the nucleus of the host cell. Its role in forming a solid capsid is necessary for the protection of viral genetic material and eventual release of new virions from the infected cell.
The FIV p24 protein participates in the viral assembly and replication processes. It is involved in pathways related to the formation of the viral capsid and budding of new virions from the host cell. During these processes p24 interacts with other structural proteins like the FIV matrix protein (p15) which together ensure the successful packaging of the virus. In the context of assembly these interactions are vital for the generation of infectious viral particles.
FIV p24 protein is closely associated with feline immunodeficiency a disease similar to HIV in humans. The presence of antibodies against p24 serves as a diagnostic marker for FIV infection in cats. Additionally the immune response to p24 and its interactions with other viral proteins such as the FIV envelope glycoprotein are subjects of study in the development of potential vaccines and treatments aimed at controlling the viral infection and its progression in feline populations.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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