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AB65289

Anti-FIV p24 antibody [PAK3-2C1]

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(1 Publication)

Mouse Monoclonal GAG antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC-Fr and reacts with Feline immunodeficiency virus samples. Cited in 1 publication.

View Alternative Names

Capsid protein p24, FIV capsid protein p24, Feline immunodeficiency virus, Feline immunodeficiency virus capsid protein p24

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PAK3-2C1

Isotype

IgG1

Carrier free

No

Reacts with

Feline immunodeficiency virus

Applications

Flow Cyt, ELISA, IHC-Fr, WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Feline immunodeficiency virus": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>Detects a dominant WB bands of approximately 24kDa, and also detects p24 gag precursor bands at 36, 39, 49 and 52kDa under reducing conditions in Western blotting.</p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Feline Immunodeficiency Virus (FIV) p24 protein also known as the FIV capsid protein plays a mechanical role in the assembly and stability of the viral core. It has a molecular mass of approximately 24 kDa. This protein is expressed within infected feline cells where it forms the central part of the viral capsid a structure that encapsulates the viral RNA genome and associated proteins. The proper formation of the capsid is essential for the viral particle's integrity and its ability to successfully infect host cells.
Biological function summary

The FIV p24 protein functions as a critical component of the viral capsid complex. It facilitates the encapsidation of the viral genome and interacts with other viral proteins such as reverse transcriptase and integrase during the viral life cycle. The p24 protein aids in the transport of retroviral complexes to the nucleus of the host cell. Its role in forming a solid capsid is necessary for the protection of viral genetic material and eventual release of new virions from the infected cell.

Pathways

The FIV p24 protein participates in the viral assembly and replication processes. It is involved in pathways related to the formation of the viral capsid and budding of new virions from the host cell. During these processes p24 interacts with other structural proteins like the FIV matrix protein (p15) which together ensure the successful packaging of the virus. In the context of assembly these interactions are vital for the generation of infectious viral particles.

FIV p24 protein is closely associated with feline immunodeficiency a disease similar to HIV in humans. The presence of antibodies against p24 serves as a diagnostic marker for FIV infection in cats. Additionally the immune response to p24 and its interactions with other viral proteins such as the FIV envelope glycoprotein are subjects of study in the development of potential vaccines and treatments aimed at controlling the viral infection and its progression in feline populations.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS biology 23:e3003135 PubMed40310862

2025

The bacterial type three secretion system induces mechanoporation of vacuolar membranes.

Applications

Unspecified application

Species

Unspecified reactive species

Léa Swistak,Marvin Albert,Camila Valenzuela,Elif Begum Gokerkucuk,François Bontems,Stéphane Tachon,Keith T Egger,Anastasia D Gazi,Anna Sartori-Rupp,Cammie F Lesser,Perrine Paul-Gilloteaux,Jean-Yves Tinevez,Matthijn Vos,Jost Enninga
View all publications

Product promise

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