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AB80264

Anti-FJX1 antibody

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(3 Publications)

Rabbit Polyclonal FJX1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Four-jointed box protein 1.

View Alternative Names

Four-jointed box protein 1, Four-jointed protein homolog, FJX1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human Four-jointed box protein 1. The exact immunogen used to generate this antibody is proprietary information.

Q86VR8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FJX1 protein also known as Four Jointed Box 1 is a signaling protein with a mass of approximately 53 kDa. It plays a significant role in cellular processes through its mechanistic function as a regulator of cell polarity and growth. Researchers have observed FJX1 expression in various tissues including the brain liver and developing skeletal muscle. Its activity is important during embryonic development where it influences morphogenetic movements and cellular orientation.
Biological function summary

Four Jointed Box 1 interacts with core signaling pathways that affect developmental processes and tissue function. The protein is not directly part of a larger complex but interacts with other molecules to perform its function. Its presence influences planar cell polarity impacting how cells orient themselves within a plane of tissue. This regulation is important for correct tissue structure and function which affects how organs develop and maintain their physiological roles.

Pathways

FJX1 is part of the Wnt/planar cell polarity (PCP) signaling pathway. This pathway plays a critical role in developmental processes like neural tube closure and cochlea orientation. It also interacts with the Fat/Ds signaling axis closely related to the Dachsous and Fat atypical cadherins which highlights its role in cell communication and signal transduction critical for maintaining cell orientation and polarity within tissues.

Abnormalities in FJX1 expression or function relate to disorders like congenital heart defects and scoliosis. Studies have shown that disturbances in the Wnt/PCP pathway can lead to these conditions implicating FJX1 in their pathogenesis. Additionally through these pathways FJX1 interacts with proteins such as Van Gogh-like 2 which further emphasizes its role in maintaining proper tissue development and alignment during both embryonic and adult phases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as an inhibitor of dendrite extension and branching.
See full target information Four-jointed box protein 1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

World journal of surgical oncology 21:61 PubMed36823639

2023

Identification of critical prognosis signature associated with lymph node metastasis of stomach adenocarcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohui Wang,Wei Zhang,Yulin Guo,Yifei Zhang,Xiaofeng Bai,Yibin Xie

Reproductive sciences (Thousand Oaks, Calif.) 25:207-213 PubMed28673206

2017

Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis.

Applications

Unspecified application

Species

Unspecified reactive species

Hye Jin Chang,Jung-Yoon Yoo,Tae Hoon Kim,Asgerally T Fazleabas,Steven L Young,Bruce A Lessey,Jae-Wook Jeong

PloS one 8:e69660 PubMed23922772

2013

Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma.

Applications

ICC/IF

Species

Human

Nicole T Al-Greene,Anna L Means,Pengcheng Lu,Aixiang Jiang,Carl R Schmidt,A Bapsi Chakravarthy,Nipun B Merchant,M Kay Washington,Bing Zhang,Yu Shyr,Natasha G Deane,R Daniel Beauchamp
View all publications
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Product promise

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