AB233409

Anti-FKBPL antibody

Name: Anti-FKBPL antibody (ab233409) | Abcam
Brand: Abcam Limited
SKU: AB233409
Price: 510 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal FKBPL antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FKBPL.

View Alternative Names

DIR1, NG7, FKBPL, FK506-binding protein-like, WAF-1/CIP1 stabilizing protein 39, WISp39

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBPL antibody (AB233409)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBPL antibody (AB233409)

Formalin-fixed, paraffin-embedded human liver tissue stained for FKBPL using ab233409 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-FKBPL antibody (AB233409)

All lanes:

Western blot - Anti-FKBPL antibody (ab233409) at 2 µg/mL

All lanes:

HL-60 (Human promyelocytic leukemia cell line) cell lysate

Predicted band size: 38 kDa

false

Supplier Data

Western blot - Anti-FKBPL antibody (AB233409)

All lanes:

Western blot - Anti-FKBPL antibody (ab233409) at 2 µg/mL

All lanes:

Mouse testis tissue lysate

Predicted band size: 38 kDa

false

Supplier Data

Western blot - Anti-FKBPL antibody (AB233409)

All lanes:

Western blot - Anti-FKBPL antibody (ab233409) at 2 µg/mL

All lanes:

Recombinant human FKBPL protein

Predicted band size: 38 kDa

false

Supplier Data

Western blot - Anti-FKBPL antibody (AB233409)

All lanes:

Western blot - Anti-FKBPL antibody (ab233409) at 2 µg/mL

All lanes:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate

Predicted band size: 38 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FKBPL.

Q9UIM3

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab233409 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FKBPL also known as FK506 binding protein-like is a protein encoded by the FKBPL gene. It has a molecular mass of approximately 37 kDa. FKBPL plays an important role in protein folding and stability due to its chaperone-like functions. It is expressed in various tissues including the brain liver kidney and placenta. The protein is associated with the immunophilin protein family which is known for involvement in immunoregulation and protein folding.

Biological function summary

FKBPL interacts with other cellular components like Hsp90 as part of a molecular complex. This interaction aids in proper protein folding and maintaining protein homeostasis within cells. FKBPL contributes to important biological processes such as cell cycle regulation and response to stress particularly in the context of DNA repair and cellular survival. Its influence extends to various physiological roles including angiogenesis and cell migration through its participation in the stabilization and modulation of other cellular proteins.

Pathways

FKBPL engages in the Hsp90-dependent chaperone pathway and the estrogen receptor signaling pathway. These pathways are important for maintaining hormone receptor functions and cellular stress responses. The protein interacts with other molecules like Hsp90 and estrogen receptor alpha emphasizing its role in maintaining receptor stability and function. This modulation is significant in cells responding to external and internal signals which require precise regulation of protein activities.

FKBPL plays a notable role in cancer and cardiovascular diseases. Its involvement in angiogenesis and estrogen receptor signaling links FKBPL to tumor growth and progression as well as resistance to therapies. Aberrant expression of FKBPL has been associated with breast cancer where it interacts with proteins such as HER2 and estrogen receptor influencing tumor growth dynamics. Additionally FKBPL influences cardiovascular health through its roles in vascular biology potentially affecting conditions like atherosclerosis.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

See full target information FKBPL

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107891 PubMed37766980

2023

Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor colitis.

Applications

Unspecified application

Species

Unspecified reactive species

Mick J M van Eijs,José J M Ter Linde,Matthijs J D Baars,Mojtaba Amini,Miangela M Laclé,Eelco C Brand,Eveline M Delemarre,Julia Drylewicz,Stefan Nierkens,Rik J Verheijden,Bas Oldenburg,Yvonne Vercoulen,Karijn P M Suijkerbuijk,Femke van Wijk

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FKBPL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBPL antibody (AB233409)

Western blot - Anti-FKBPL antibody (AB233409)

Western blot - Anti-FKBPL antibody (AB233409)

Western blot - Anti-FKBPL antibody (AB233409)

Western blot - Anti-FKBPL antibody (AB233409)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Product promise