JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB233426

Anti-FKBPL antibody

0

(1 Review)

|

(1 Publication)

Rabbit Polyclonal FKBPL antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Fkbpl.

View Alternative Names

DIR1, NG7, FKBPL, FK506-binding protein-like, WAF-1/CIP1 stabilizing protein 39, WISp39

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBPL antibody (AB233426)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBPL antibody (AB233426)

Formalin-fixed, paraffin-embedded mouse testis tissue stained for FKBPL using ab233426 at 20 μg/ml in immunoistochemical analysis. DAB staining.

Western blot - Anti-FKBPL antibody (AB233426)
  • WB

Supplier Data

Western blot - Anti-FKBPL antibody (AB233426)

All lanes:

Western blot - Anti-FKBPL antibody (ab233426) at 2 µg/mL

All lanes:

Jurkat (human T cell leukemia cell line from peripheral blood) cell lysate

Predicted band size: 38 kDa

false

Western blot - Anti-FKBPL antibody (AB233426)
  • WB

Supplier Data

Western blot - Anti-FKBPL antibody (AB233426)

All lanes:

Western blot - Anti-FKBPL antibody (ab233426) at 2 µg/mL

All lanes:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate

Predicted band size: 38 kDa

false

Western blot - Anti-FKBPL antibody (AB233426)
  • WB

Supplier Data

Western blot - Anti-FKBPL antibody (AB233426)

All lanes:

Western blot - Anti-FKBPL antibody (ab233426) at 2 µg/mL

All lanes:

MCF7 (human breast adenocarcinoma cell line) cell lysate

Predicted band size: 38 kDa

false

Western blot - Anti-FKBPL antibody (AB233426)
  • WB

Supplier Data

Western blot - Anti-FKBPL antibody (AB233426)

All lanes:

Western blot - Anti-FKBPL antibody (ab233426) at 2 µg/mL

All lanes:

Recombinant mouse FKBPL protein

Predicted band size: 38 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Fkbpl.

O35450

style
left-column

Alternative Products

Primary Antibodies

AB233409

Anti-FKBPL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBPL antibody (AB233409)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB234730

Anti-UNC45B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNC45B antibody (AB234730)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB183346

Anti-TN-X antibody [SP230]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (AB183346)

  • 0
  • 0
Primary Antibodies

AB247258

Anti-ZAP70 antibody [YE291] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-ZAP70 antibody [YE291] - BSA and Azide free (AB247258)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FKBPL also known as FK506 binding protein-like is a protein encoded by the FKBPL gene. It has a molecular mass of approximately 37 kDa. FKBPL plays an important role in protein folding and stability due to its chaperone-like functions. It is expressed in various tissues including the brain liver kidney and placenta. The protein is associated with the immunophilin protein family which is known for involvement in immunoregulation and protein folding.
Biological function summary

FKBPL interacts with other cellular components like Hsp90 as part of a molecular complex. This interaction aids in proper protein folding and maintaining protein homeostasis within cells. FKBPL contributes to important biological processes such as cell cycle regulation and response to stress particularly in the context of DNA repair and cellular survival. Its influence extends to various physiological roles including angiogenesis and cell migration through its participation in the stabilization and modulation of other cellular proteins.

Pathways

FKBPL engages in the Hsp90-dependent chaperone pathway and the estrogen receptor signaling pathway. These pathways are important for maintaining hormone receptor functions and cellular stress responses. The protein interacts with other molecules like Hsp90 and estrogen receptor alpha emphasizing its role in maintaining receptor stability and function. This modulation is significant in cells responding to external and internal signals which require precise regulation of protein activities.

FKBPL plays a notable role in cancer and cardiovascular diseases. Its involvement in angiogenesis and estrogen receptor signaling links FKBPL to tumor growth and progression as well as resistance to therapies. Aberrant expression of FKBPL has been associated with breast cancer where it interacts with proteins such as HER2 and estrogen receptor influencing tumor growth dynamics. Additionally FKBPL influences cardiovascular health through its roles in vascular biology potentially affecting conditions like atherosclerosis.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.
See full target information FKBPL
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

EBioMedicine 50:166-177 PubMed31761616

2019

Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Qiu,Tianli Chen,Rongqi Sun,Zengli Liu,Xiaoming Zhang,Zhipeng Li,Yunfei Xu,Zongli Zhang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com