Anti-FLVCR1 antibody

Target data

Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis (PubMed : 37100056, PubMed : 38693265, PubMed : 38778100). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed : 38693265, PubMed : 38778100). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed : 38693265, PubMed : 38778100). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed : 15369674, PubMed : 20610401, PubMed : 22483575, PubMed : 23187127, PubMed : 27923065).. Isoform 1. Uniporter that mediates the transport of extracellular choline and ethanolamine into cells (PubMed : 37100056, PubMed : 38693265). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed : 38693265). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed : 38693265). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed : 15369674, PubMed : 20610401, PubMed : 22483575, PubMed : 23187127, PubMed : 27923065). Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity (PubMed : 20610401). Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies (PubMed : 20610401, PubMed : 23187127). Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway (PubMed : 20610401). Does not export bilirubin (PubMed : 20610401). The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (PubMed : 20610401, PubMed : 23187127).. Isoform 2. Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.. Isoform 1. (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro.