AB181884

Anti-FNDC5 antibody - C-terminal

Name: Anti-FNDC5 antibody - C-terminal (ab181884) | Abcam
Brand: Abcam Limited
SKU: AB181884
Price: 535 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(14 Publications)

Rabbit Polyclonal FNDC5 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Synthetic Peptide within Human FNDC5.

View Alternative Names

FRCP2, FNDC5, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human FNDC5. The exact immunogen used to generate this antibody is proprietary information.

Q8NAU1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Irisin. Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.

See full target information FNDC5

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Mechanobiology in medicine 3:100148 PubMed40995564

2025

Theta-shaking mitigates cognitive-emotional decline via subiculum and ventral septum metabolic plasticity.

Applications

Unspecified application

Species

Unspecified reactive species

Runhong Yao,Kouji Yamada,Hirohide Sawada,Takeshi Chihara,Naoki Aizu,Kazuhiro Nishii

Frontiers in physiology 16:1616693 PubMed40692696

2025

Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study.

Applications

Unspecified application

Species

Unspecified reactive species

Roberto Bonanni,Angela Falvino,Antonio Matticari,Anna Maria Rinaldi,Giovanna D'Arcangelo,Pierangelo Cifelli,Riccardo Iundusi,Elena Gasbarra,Virginia Tancredi,Ida Cariati,Umberto Tarantino

Journal of functional morphology and kinesiology 10: PubMed39846667

2025

Bone Adaptations to a Whole Body Vibration Protocol in Murine Models of Different Ages: A Preliminary Study on Structural Changes and Biomarker Evaluation.

Applications

Unspecified application

Species

Unspecified reactive species

Ida Cariati,Roberto Bonanni,Cristian Romagnoli,Lucio Caprioli,Giovanna D'Arcangelo,Virginia Tancredi,Giuseppe Annino

Scientific reports 14:26881 PubMed39505986

2024

FNDC5 affects invasion and migration of oral cancer by inhibiting PI3K/Akt/Snail signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Zhao,Dongyang Xu,Xiumei Wang,Xiaofeng Wang

Heliyon 10:e29090 PubMed38638979

2024

FNDC5/irisin mediates the protective effects of Innovative theta-shaking exercise on mouse memory.

Applications

Unspecified application

Species

Unspecified reactive species

Runhong Yao,Kouji Yamada,Sho Izawa,Takumi Kito,Hirohide Sawada,Takeshi Chihara,Naoki Aizu,Daiki Iwata,Kazuhiro Nishii

International journal of molecular sciences 23: PubMed36142305

2022

Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations.

Applications

Unspecified application

Species

Unspecified reactive species

Ida Cariati,Roberto Bonanni,Gabriele Pallone,Cristian Romagnoli,Anna Maria Rinaldi,Giuseppe Annino,Giovanna D'Arcangelo,Virginia Tancredi

Frontiers in oncology 12:852095 PubMed35392237

2022

FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Huayuan Liu,Lei Zhao,Mengya Wang,Kexin Yang,Zhipeng Jin,Chengjian Zhao,Guangjun Shi

Archives of oral biology 124:105061 PubMed33508625

2021

FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yang,Helen Pullisaar,Maria A Landin,Catherine Anne Heyward,Maria Schröder,Tianxiang Geng,Maria Grano,Janne Elin Reseland

Antioxidants (Basel, Switzerland) 9: PubMed32882839

2020

Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Feng-Sheng Wang,Chung-Wen Kuo,Jih-Yang Ko,Yu-Shan Chen,Shao-Yu Wang,Huei-Jing Ke,Pei-Chen Kuo,Chin-Huei Lee,Jian-Ching Wu,Wen-Bin Lu,Ming-Hong Tai,Holger Jahr,Wei-Shiung Lian

Kidney & blood pressure research 44:479-495 PubMed31238319

2019

Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Jing Pan,Si-Jia Zhou,Jin Feng,Qiong Bai,La-Ta A,Ai-Hua Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FNDC5 antibody - C-terminal

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

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Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (14)

Product promise