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AB233142

Anti-Folate Receptor 4 antibody

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(1 Publication)

Rabbit Polyclonal Folate Receptor 4 antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Izumo1r aa 50 to C-terminus.

View Alternative Names

Folbp3, Folr4, Juno, Izumo1r, Sperm-egg fusion protein Juno, Folate receptor 4, Folate receptor delta, Folate-binding protein 3, IZUMO1 receptor protein JUNO, FR-delta

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Folate Receptor 4 antibody (AB233142)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Folate Receptor 4 antibody (AB233142)

Formalin-fixed, paraffin-embedded mouse lung tissue stained for Folate Receptor 4 using ab233142 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Folate Receptor 4 antibody (AB233142)
  • WB

Supplier Data

Western blot - Anti-Folate Receptor 4 antibody (AB233142)

All lanes:

Western blot - Anti-Folate Receptor 4 antibody (ab233142) at 3 µg/mL

All lanes:

Mouse thymus lysate

Predicted band size: 29 kDa

false

Western blot - Anti-Folate Receptor 4 antibody (AB233142)
  • WB

Supplier Data

Western blot - Anti-Folate Receptor 4 antibody (AB233142)

All lanes:

Western blot - Anti-Folate Receptor 4 antibody (ab233142) at 2 µg/mL

All lanes:

Recombinant mouse Folate Receptor 4 protein

Predicted band size: 29 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Mouse Izumo1r aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9EQF4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Folate Receptor 4 (FR4) also known as delta folate receptor is involved in the high-affinity binding and transport of folate and folate analogs across the cell membrane. Folate is an essential vitamin B9 derivative which cells use for important functions like DNA synthesis and repair. FR4 has a mass of approximately 30 kilodaltons. Researchers have found this receptor mainly on the surface of activated T cells which play an important role in the immune system.
Biological function summary

FR4 aids in the uptake of folate compounds necessary for cellular proliferation and survival. It is not generally part of a larger protein complex but it competes with other folate receptors like folate receptor alpha for binding to available folate molecules. The receptor’s function directly supports T cell activity and survival impacting immune responses.

Pathways

The folate receptor FR4 contributes to immune response pathways by ensuring an adequate supply of folate for T cells. It is a part of the broader folate metabolism pathway which also involves proteins such as dihydrofolate reductase (DHFR) that further process folate for nucleic acid synthesis. This participation in folate metabolism supports not only primary cellular functions but also the specialized activity of immune cells.

FR4 is notably associated with autoimmune diseases such as rheumatoid arthritis where abnormal expression levels have been observed in T cells. Also FR4 connects indirectly to cancer as altered folate metabolism can contribute to oncogenesis. Although it functions separately from proteins like thymidylate synthase which is directly involved in cancer proliferation both are part of the overall metabolic pathways impacting disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808, PubMed : 27416963). The IZUMO1 : IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808). Does not bind folate (PubMed : 24739963).
See full target information Izumo1r
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of hepatocellular carcinoma 10:2337-2353 PubMed38163053

2024

Hepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Inhibits FIH-1 Expression to Promote Tumor Angiogenesis in HBV-Related Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Han Chen,Dan Cao,Ning Han,Mingming Zhang,Wei Jiang,Xin Wang,Qinmin Zeng,Hong Tang
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