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AB228451

Anti-Folate Receptor 4 antibody [TH6]

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(1 Publication)

Rat Monoclonal Folate Receptor 4 antibody. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Tissue preparation containing Izumo1r protein.

View Alternative Names

Folbp3, Folr4, Juno, Izumo1r, Sperm-egg fusion protein Juno, Folate receptor 4, Folate receptor delta, Folate-binding protein 3, IZUMO1 receptor protein JUNO, FR-delta

2 Images
Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)

Flow cytometric analysis of mouse splenocytes labeling Folate Receptor 4 with ab228451 at 0.5 μg/106 cells.

Cells were first stained with an anti-mCD3 APC conjugated; mCD3 APC positive cells were gated and further analyzed for mouse Folate Receptor 4 using ab228451. Goat anti-Rat PE was used as the secondary antibody.

Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Folate Receptor 4 antibody [TH6] (AB228451)

Flow cytometric analysis of mouse thymocytes labeling Folate Receptor 4 with ab228451 at 0.5 μg/106 cells.

Cells were first stained with an anti-mCD3 APC conjugated; mCD3 APC positive cells were gated and further analyzed for mouse Folate Receptor 4 using ab228451. Goat anti-Rat PE was used as the secondary antibody.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

TH6

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Tissue preparation containing Izumo1r protein. The exact immunogen used to generate this antibody is proprietary information.

Q9EQF4

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Alternative Products

Primary Antibodies

AB233142

Anti-Folate Receptor 4 antibody

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Complementary Products

Primary Antibodies

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

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Primary Antibodies

AB177937

Anti-SIGIRR antibody [EPR12638]

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Cell Lines & Lysates

AB264921

Human FOLR1 (Folate Binding Protein/FBP) knockout HeLa cell line

Advanced Validation

Immunocytochemistry/ Immunofluorescence - Human FOLR1 (Folate Binding Protein/FBP) knockout HeLa cell line (AB264921)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.5-1 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from TCS.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Folate Receptor 4 (FR4) also known as delta folate receptor is involved in the high-affinity binding and transport of folate and folate analogs across the cell membrane. Folate is an essential vitamin B9 derivative which cells use for important functions like DNA synthesis and repair. FR4 has a mass of approximately 30 kilodaltons. Researchers have found this receptor mainly on the surface of activated T cells which play an important role in the immune system.
Biological function summary

FR4 aids in the uptake of folate compounds necessary for cellular proliferation and survival. It is not generally part of a larger protein complex but it competes with other folate receptors like folate receptor alpha for binding to available folate molecules. The receptor’s function directly supports T cell activity and survival impacting immune responses.

Pathways

The folate receptor FR4 contributes to immune response pathways by ensuring an adequate supply of folate for T cells. It is a part of the broader folate metabolism pathway which also involves proteins such as dihydrofolate reductase (DHFR) that further process folate for nucleic acid synthesis. This participation in folate metabolism supports not only primary cellular functions but also the specialized activity of immune cells.

FR4 is notably associated with autoimmune diseases such as rheumatoid arthritis where abnormal expression levels have been observed in T cells. Also FR4 connects indirectly to cancer as altered folate metabolism can contribute to oncogenesis. Although it functions separately from proteins like thymidylate synthase which is directly involved in cancer proliferation both are part of the overall metabolic pathways impacting disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808, PubMed : 27416963). The IZUMO1 : IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed : 24739963, PubMed : 26859261, PubMed : 27309808). Does not bind folate (PubMed : 24739963).
See full target information Izumo1r
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell communication and signaling 19:e70016 PubMed40401147

2025

ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia-derived mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Weihua Ye,Zheng Liu,Yaoxi Liu,Han Xiao,Qian Tan,An Yan,Guanghui Zhu
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Product promise

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