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AB234190

Anti-FOLR2 antibody [EM-35]

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(2 Publications)

Mouse Monoclonal FOLR2 antibody. Suitable for Flow Cyt and reacts with Transfected cell line samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing FOLR2 protein.

View Alternative Names

Folate receptor beta, FR-beta, Folate receptor 2, Placental folate-binding protein, FBP, FOLR2

1 Images
Flow Cytometry - Anti-FOLR2 antibody [EM-35] (AB234190)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-FOLR2 antibody [EM-35] (AB234190)

Flow cytometric analysis of FOLR2 transfectants labeling FOLR2 with ab234190 (red) compared with a negative control (blue). Surface staining.

  • 578 PE

    PE Anti-FOLR2 antibody [EM-35]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

EM-35

Isotype

IgG1

Carrier free

No

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing FOLR2 protein. The exact immunogen used to generate this antibody is proprietary information.

P14207

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" }, "Transfected cell line": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purity > 95% (by SDS-PAGE).
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Folate receptor beta also known as FOLR2 is a protein with a molecular mass of approximately 32 kDa. It facilitates the transport of folate into cells. FOLR2 binds folate with high affinity and plays an important role in cellular metabolism. The receptor is mainly expressed in the placenta and certain myeloid cells such as macrophages and monocytes. Its expression is also notable in certain cancer cells but not in most normal tissues.
Biological function summary

Folate receptor beta plays a significant role in folate uptake contributing to DNA synthesis and repair processes. FOLR2 as a part of the cell membrane forms a complex with other molecules to capture and internalize folate from the extracellular environment. This process is essential for the proliferation and survival of cells that require large amounts of folate including developing embryos and certain immune cells.

Pathways

The function of folate receptor beta connects with the folate-mediated one-carbon metabolism pathway critical for nucleotide biosynthesis and methylation reactions. This pathway influences the synthesis of purines and pyrimidines supporting DNA replication and repair. FOLR2 interacts with folate transport proteins and enzymes involved in the methionine cycle which interlinks with amino acid metabolism and epigenetic regulation.

Folate receptor beta is associated with rheumatoid arthritis and ovarian cancer. In rheumatoid arthritis FOLR2 expression on activated macrophages indicates its potential as a biomarker and target for therapy. The overexpression of FOLR2 in ovarian cancer makes it a target for folate-linked therapeutic agents. The relationship between FOLR2 and immune proteins in inflammatory conditions highlights its role in modulating immune responses in disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
See full target information FOLR2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Breast cancer research : BCR 27:31 PubMed40045365

2025

Unveiling the key mechanisms of FOLR2+ macrophage-mediated antitumor immunity in breast cancer using integrated single-cell RNA sequencing and bulk RNA sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Sixuan Wu,Baohong Jiang,Zhimin Li,Yuanbin Tang,Lunqi Luo,Wenjie Feng,Yiling Jiang,Yeru Tan,Yuehua Li

PloS one 8:e60136 PubMed23565196

2013

The TNF-family cytokine TL1A inhibits proliferation of human activated B cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara Cavallini,Ornella Lovato,Anna Bertolaso,Luciano Pacelli,Elisa Zoratti,Elisabetta Zanolin,Mauro Krampera,Alberto Zamò,Cristina Tecchio,Marco A Cassatella,Giovanni Pizzolo,Maria T Scupoli
View all publications
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