Anti-Forkhead box protein O/dFOXO antibody - N-terminal

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

FOXO proteins are involved in multiple cellular processes that maintain homeostasis. When in the cytoplasm FOXO proteins stay inactive but they translocate to the nucleus when activated. They are not part of a large protein complex but their function can be influenced by interaction with other proteins such as Akt which phosphorylates and inactivates them. Once in the nucleus FOXO proteins facilitate the transcription of genes that handle metabolic regulation cell growth inhibition and longevity.

Pathways

FOXO proteins play significant roles in the PI3K-Akt signaling and insulin signaling pathways. Within these pathways FOXO proteins act as key regulators often interacting with proteins like Akt which phosphorylates FOXO and leads to its exclusion from the nucleus. These pathways demonstrate how FOXO proteins integrate environmental signals to mediate cellular responses like stress resistance and metabolism regulation.