Rabbit Polyclonal Forkhead box protein O/dFOXO antibody. N-terminal. Suitable for WB and reacts with Drosophila melanogaster samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Drosophila melanogaster foxo.
Constituents: 2% Sucrose, 1.21% Tris buffer, 0.75% Glycine
| WB | |
|---|---|
| Drosophila melanogaster | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Drosophila melanogaster | Dilution info Use at an assay dependent concentration. | Notes - |
Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.
Afx, CG3143, foxo, Forkhead box protein O, dFOXO, Protein FKHR
Rabbit Polyclonal Forkhead box protein O/dFOXO antibody. N-terminal. Suitable for WB and reacts with Drosophila melanogaster samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Drosophila melanogaster foxo.
Constituents: 2% Sucrose, 1.21% Tris buffer, 0.75% Glycine
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Forkhead box protein O (FOXO) also known as dFOXO in Drosophila is a transcription factor notable for its role in regulating gene expression. FOXO proteins typically weigh between 70 and 80 kDa. They are widely expressed in various tissues including the liver pancreas and adipose tissue. Mechanically FOXO proteins can bind to DNA sequences and influence the transcription of genes involved in cell cycle regulation apoptosis and oxidative stress response.
FOXO proteins are involved in multiple cellular processes that maintain homeostasis. When in the cytoplasm FOXO proteins stay inactive but they translocate to the nucleus when activated. They are not part of a large protein complex but their function can be influenced by interaction with other proteins such as Akt which phosphorylates and inactivates them. Once in the nucleus FOXO proteins facilitate the transcription of genes that handle metabolic regulation cell growth inhibition and longevity.
FOXO proteins play significant roles in the PI3K-Akt signaling and insulin signaling pathways. Within these pathways FOXO proteins act as key regulators often interacting with proteins like Akt which phosphorylates FOXO and leads to its exclusion from the nucleus. These pathways demonstrate how FOXO proteins integrate environmental signals to mediate cellular responses like stress resistance and metabolism regulation.
FOXO proteins have associations with cancer and diabetes. Mutations or dysregulation of FOXO activity can contribute to tumor development by allowing unchecked cell proliferation. Similarly in diabetes impaired insulin signaling affects FOXO function leading to alterations in glucose metabolism. In cancer FOXO can interact with proteins like p53 while in diabetes its activity can influence insulin-responsive pathways showcasing its diverse role in disease dynamics.
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