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AB153947

Anti-FOXB1 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal FOXB1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FOXB1 aa 250 to C-terminus.

View Alternative Names

FKH5, FOXB1, Forkhead box protein B1, Transcription factor FKH-5

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-FOXB1 antibody - C-terminal (AB153947)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FOXB1 antibody - C-terminal (AB153947)

Immunofluorescence analysis of paraformaldehyde-fixed HepG2, labeling FOXB1 with ab153947 at 1/200 dilution.

Western blot - Anti-FOXB1 antibody - C-terminal (AB153947)
  • WB

Unknown

Western blot - Anti-FOXB1 antibody - C-terminal (AB153947)

10% SDS PAGE

All lanes:

Western blot - Anti-FOXB1 antibody - C-terminal (ab153947) at 1/1000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 20 kDa,35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human FOXB1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q99853

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXB1 also known as Forkhead box protein B1 is a transcription factor. It typically weighs around 75 kDa. FOXB1 expression predominantly occurs in the brain where it regulates gene expression critical for development and function. This protein binds to DNA influencing the transcription of target genes which plays a role in development processes.
Biological function summary

FOXB1 influences nervous system development and function acting as part of a complex that modulates transcriptional activity. Its role extends to maintaining cellular proliferation and differentiation. FOXB1's interaction with specific DNA elements shows its contribution to neurogenesis and axonal guidance which are essential for proper brain structure and function.

Pathways

FOXB1 operates within the Hedgehog and Wnt signaling pathways which are essential for cell fate determination and growth in the brain. It works alongside proteins such as Gli in the Hedgehog signaling pathway to influence developmental processes. In the Wnt signaling pathway FOXB1 interacts with beta-catenin-related functions important for synaptic and neuronal activities in the brain.

FOXB1's involvement relates to neurodevelopmental disorders and glioblastoma. Altered FOXB1 expression or function can contribute to improper brain development leading to neurodevelopmental issues. In glioblastoma FOXB1 interacts with FoxG1 suggesting roles in tumor progression. Studying FOXB1 interactions offers insights into potential therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor expressed by neural progenitor cells in specific regions of the embryonic neuroepithelium. Essential for the mammillary nuclei maintenance. Negatively regulates the proliferation of oligodendrocyte progenitors and promotes oligodendrocyte maturation. Also expressed in mammary glands, plays a role in lactation, controls development of mammary glands and the inferior colliculi of the midbrain in the central nervous system that regulates the milk-ejection reflex.
See full target information FOXB1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:643522 PubMed33791301

2021

LRH1 Acts as an Oncogenic Driver in Human Osteosarcoma and Pan-Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Song,Weiwei An,Hongmei Wang,Yuanren Gao,Jihua Han,Chenguang Hao,Lin Chen,Shilong Liu,Ying Xing
View all publications
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Product promise

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