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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal FOXH1 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FOXH1.
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Forkhead box protein H1, Forkhead activin signal transducer 1, Forkhead activin signal transducer 2, Fast-1, hFAST-1, Fast-2, FOXH1, FAST1, FAST2
Rabbit Polyclonal FOXH1 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FOXH1.
Forkhead box protein H1, Forkhead activin signal transducer 1, Forkhead activin signal transducer 2, Fast-1, hFAST-1, Fast-2, FOXH1, FAST1, FAST2
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
ab189960 is predicted to not cross-react with any other members of the forkhead box family.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
FOXH1 functions as an essential component in cell signaling by acting as a transcriptional activator. It interacts with other proteins as part of the transforming growth factor-beta (TGF-β) signaling pathway to influence cell fate determination and development. FOXH1 operates within complexes partnering frequently with SMAD2 and SMAD3 to effectively mediate cellular responses to extracellular signals.
The transcription factor FOXH1 also known as Forkhead Box H1 FOXH1a or Fast-1 plays a significant mechanical role in gene regulation. With a mass of approximately 45 kDa FOXH1 is expressed in various tissues including embryonic and adult tissues. It particularly localizes in the nucleus reflecting its function in modulating the expression of target genes through DNA binding.
FOXH1 occupies a critical position within the TGF-β signaling and Nodal signaling pathways. These pathways are deeply involved in embryonic patterning and the regulation of cell cycle progression. FOXH1 interacts with proteins such as SMAD2 SMAD4 and NODAL which work together to activate specific gene sets essential for embryonic development and tissue homeostasis.
FOXH1 links with conditions rooted in developmental defects and cancer. Mutations or dysregulation in FOXH1 expression associate with congenital disorders affecting the heart and other organs. Also its interaction with proteins like NODAL and SMAD factors implicates it in the progression of certain cancers by promoting aberrant cell proliferation and differentiation. Understanding FOXH1's role in these processes aids in the development of targeted therapeutic strategies.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
All lanes: Western blot - Anti-FOXH1 antibody - N-terminal (AB189960) at 1 µg/mL
All lanes: human liver tissue lysate
Predicted band size: 39 kDa
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate tissue labeling FOXH1 with ab189960 at 5 μg/ml.
Immunofluorescence analysis of human liver tissue labeling FOXH1 with ab189960 at 20 μg/ml.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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