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AB113424

Anti-FOXI3 antibody

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(1 Publication)

Goat Polyclonal FOXI3 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Foxi3 aa 200-300.

View Alternative Names

Forkhead box protein I3

2 Images
Western blot - Anti-FOXI3 antibody (AB113424)
  • WB

Supplier Data

Western blot - Anti-FOXI3 antibody (AB113424)

Detected by chemiluminescence.

All lanes:

Western blot - Anti-FOXI3 antibody (ab113424) at 1 µg/mL

All lanes:

Rat Skin lysate (35µg protein in RIPA buffer)

Predicted band size: 43 kDa

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Western blot - Anti-FOXI3 antibody (AB113424)
  • WB

Unknown

Western blot - Anti-FOXI3 antibody (AB113424)

All lanes:

Western blot - Anti-FOXI3 antibody (ab113424) at 1 µg/mL

All lanes:

Mouse Skin lysate (in RIPA buffer) at 35 µg

Predicted band size: 43 kDa

true

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Mouse Foxi3 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

D3Z120

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>Primary incubation time: 1 hour.</p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>Primary incubation time: 1 hour.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab113424 was purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target protein FOXI3 also known as Forkhead box protein I3 functions as a transcription factor involved in regulating gene expression. It has a mass of approximately 43 kDa. FOXI3 is mainly expressed in tissues derived from the ectoderm such as skin hair follicles and tooth buds. This expression pattern suggests a role in the development and differentiation of these tissues.
Biological function summary

The FOXI3 protein plays a central role in the development of ectodermal structures. It does not form part of a larger protein complex but operates by binding to DNA and controlling the expression of genes necessary for the development and morphogenesis of hair and dental structures. Its regulation of these developmental processes highlights its importance in proper ectodermal tissue function.

Pathways

The FOXI3 protein participates in the WNT signaling pathway which is important for cell differentiation and proliferation in ectodermal tissues. It also interacts with other transcription factors such as Lef1 to regulate hair follicle development. The interplay between FOXI3 and these proteins highlights its involvement in pathways that determine ectodermal tissue fate.

Genetic mutations in FOXI3 have been linked to ectodermal dysplasia a condition characterized by abnormal development of the skin hair and teeth. Research has shown that mutations can disrupt its usual function leading to these developmental issues. Additionally FOXI3 shows a connection with the protein MSX1 which also influences tooth development further implicating its role in dental disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development (PubMed : 24650709, PubMed : 26550799, PubMed : 26992132, PubMed : 30467319). May act as a pioneer transcription factor during pharyngeal arch development (PubMed : 26550799, PubMed : 26992132). Required for epithelial cell differentiation within the epidermis (PubMed : 26450968). Acts at multiple stages of otic placode induction : necessary for preplacodal ectoderm to execute an inner ear program (PubMed : 26550799). Required for hair follicle stem cell specification (PubMed : 26992132). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (PubMed : 31412026).
See full target information Foxi3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 8:37717-37729 PubMed28465479

2017

KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Rongliang Tong,Beng Yang,Heng Xiao,Chuanhui Peng,Wendi Hu,Xiaoyu Weng,Shaobing Cheng,Chengli Du,Zhen Lv,Chaofeng Ding,Lin Zhou,Haiyang Xie,Jian Wu,Shusen Zheng
View all publications
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Product promise

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