Anti-FOXJ3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FOXJ3 also known as Forkhead Box J3 is a transcription factor characterized by a forkhead DNA-binding domain. Its mechanical function roots in its ability to regulate gene expression by binding to specific DNA sequences. The FOXJ3 protein has a molecular mass of approximately 53 kDa and researchers have observed its expression in various tissues such as the brain heart and skeletal muscle indicative of its widespread functional importance in different cellular contexts.

Biological function summary

FOXJ3 influences cellular differentiation and proliferation. It operates as part of transcriptional regulatory complexes which modulate gene expression important for development and cellular homeostasis. Researchers link FOXJ3 functions particularly to the embryonic development processes where it plays roles in cell lineage specification and the maintenance of stem cell populations. Insights suggest its implications in broader regulatory networks that impact organ development.

Pathways

FOXJ3 integrates into multiple developmental and signaling pathways that govern cellular growth and differentiation. This transcription factor is notably involved in the Wnt signaling pathway which is critical for developmental processes and tissue regeneration. FOXJ3 also shares regulatory connections with other members of the FOXJ family of transcription factors such as FOXO1 and FOXM1 further establishing its role in modulating cellular fate and function.

Associated diseases and disorders

Researchers have linked FOXJ3 to certain forms of cancer and neurodegenerative diseases. Aberrant expression of FOXJ3 can contribute to tumorigenic processes highlighting its potential role in cancer biology. In models of neurodegeneration altered FOXJ3 activity may disrupt normal neural function exacerbating disease progression. The interplay with proteins like β-catenin in these pathological contexts highlights the relevance of FOXJ3 as a contributor to disease mechanisms and as a potential target for therapeutic intervention.