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AB190226

Anti-FOXL1 antibody

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(4 Publications)

Rabbit Polyclonal FOXL1 antibody. Suitable for WB, IHC-P and reacts with Chinese hamster, Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human FOXL1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

FKHL11, FREAC7, FOXL1, Forkhead box protein L1, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7, FREAC-7

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL1 antibody (AB190226)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL1 antibody (AB190226)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human testis tissue labeling FOXL1 with ab190226 at 1/100 dilution.

Western blot - Anti-FOXL1 antibody (AB190226)
  • WB

Supplier Data

Western blot - Anti-FOXL1 antibody (AB190226)

All lanes:

Western blot - Anti-FOXL1 antibody (ab190226) at 1/1000 dilution

All lanes:

mouse kidney tissue lysate at 35 µg

Predicted band size: 36 kDa

false

Western blot - Anti-FOXL1 antibody (AB190226)
  • WB

Supplier Data

Western blot - Anti-FOXL1 antibody (AB190226)

All lanes:

Western blot - Anti-FOXL1 antibody (ab190226) at 1/1000 dilution

All lanes:

CHO cell lysate at 35 µg

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human, Chinese hamster

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human FOXL1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q12952

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chinese hamster": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXL1 also known as Forkhead Box L1 is a transcription factor encoded [by the FOXL1 gene] and has a mass of approximately 38 kDa. This protein is part of the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXL1 is expressed mainly in the mesenchymal cells of the gastrointestinal tract particularly in the stomach and the small intestine. Additionally it can be found in other tissues but at lower levels contributing to its role in the regulation of various cellular processes.
Biological function summary

The transcription factor FOXL1 plays a critical role in the development and differentiation of tissues within the digestive system. It functions as part of a complex that regulates mesenchymal-epithelial interactions during organogenesis particularly in the gut. FOXL1 influences the cell proliferation apoptosis and differentiation required for maintaining the homeostasis and architecture of the gastrointestinal epithelium. Its activity can modulate the expression of genes involved in the signaling pathways that are essential for tissue repair and development.

Pathways

FOXL1 impacts the hedgehog signaling and the Wnt/β-catenin pathway both of which are important to embryonic development and cell differentiation. In the hedgehog signaling pathway FOXL1 interacts with other proteins such as GLI transcription factors to modulate gene expression. Similarly the Wnt/β-catenin pathway involves FOXL1 in regulating processes linked to cell growth and differentiation in the intestinal environment often working with proteins like TCF7L2 to control target gene transcription.

FOXL1 has connections to gastrointestinal cancers and congenital disorders affecting the digestive tract. Anomalies in FOXL1 expression or function can contribute to the development of stomach cancer where it may act together with the aberrant activation of FOXO3 and CTNNB1 proteins. Additionally disruptions in the regulatory roles of FOXL1 can lead to disorders such as duodenal atresia as it is fundamental in proper gastrointestinal development and maintenance. FOXL1's involvement in these diseases highlights its significance in understanding the molecular mechanisms underlying gastrointestinal pathologies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors (By similarity).
See full target information FOXL1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer research communications 4:264-278 PubMed38165157

2024

Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Napoli,Avani A Deshpande,Deepavali Chakravarti,Kimal Rajapakshe,Preethi H Gunaratne,Cristian Coarfa,Elsa R Flores

American journal of respiratory cell and molecular biology 63:831-842 PubMed32946266

2020

FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Naoya Miyashita,Masafumi Horie,Hiroshi I Suzuki,Minako Saito,Yu Mikami,Kenichi Okuda,Richard C Boucher,Maho Suzukawa,Akira Hebisawa,Akira Saito,Takahide Nagase

Surgical laparoscopy, endoscopy & percutaneous techniques 30:395-402 PubMed32404854

2020

Clinical Value of Serum LHPP-associated miR-765 in the Prognosis of Laparoscopic or Open Hepatectomy for Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jingting Yan,Liyan He,Guang Li,Xiuda Peng,Wei Li,Xianrong Liu,Dunxue Yang,Jin Liu,Peng Zhang,Xianzhou Lu

Oncology letters 18:751-757 PubMed31289550

2019

FOXL1 overexpression is associated with poor outcome in patients with glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Ainian Chen,Lingling Zhong,Jia Lv
View all publications
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Product promise

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