AB327143

Anti-FOXL2 Antibody [CL12753]

Name: Anti-FOXL2 Antibody [CL12753] (ab327143) | Abcam
Brand: Abcam Limited
SKU: AB327143
Price: 580 USD
Availability: InStock

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Mouse Monoclonal FOXL2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FOXL2.

View Alternative Names

Forkhead box protein L2, FOXL2

8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

Immunohistochemical staining of human fallopian tube using ab327143 at 1 : 1000–1 : 2500 dilution, showing moderate nuclear positivity in stromal cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

Immunohistochemical staining of human ovarian cancer (granulosa cell tumour) using ab327143 at 1 : 1000–1 : 2500 dilution, showing strong nuclear positivity in tumor cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

Immunohistochemical staining of human ovary using ab327143 at 1 : 1000–1 : 2500 dilution, showing moderate to strong nuclear positivity in follicle (granulosa) cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

Immunohistochemistry analysis in human ovary and liver tissues using ab327143 at 1 : 1000–1 : 2500 dilution. Corresponding FOXL2 RNA-seq data are presented for the same tissues.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

Immunohistochemical staining of human ovarian cancer (sex cord tumor) using ab327143 at 1 : 1000–1 : 2500 dilution, showing strong nuclear positivity in tumor cells.

Supplier Data

Western blot - Anti-FOXL2 Antibody [CL12753] (AB327143)

Western blot analysis in human cell line K562 using ab327143 at 1 µg/ml.

All lanes:

Western blot - Anti-FOXL2 Antibody [CL12753] (ab327143)

All lanes:

Human cell line K562

Predicted band size: 38.77 kDa

false

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

Immunohistochemical staining of human liver using ab327143 at 1 : 1000–1 : 2500 dilution, showing no positivity in hepatocytes as expected.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXL2 Antibody [CL12753] (AB327143)

Immunohistochemical staining of human colon using ab327143 at 1 : 1000–1 : 2500 dilution, showing no positivity in glandular cells as expected.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CL12753

Isotype

IgG3

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human FOXL2.

P58012

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

See full target information FOXL2

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Product promise

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