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AB234077

Anti-FOXM1 antibody [6F11A8]

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(3 Publications)

Mouse Monoclonal FOXM1 antibody. Suitable for Flow Cyt, WB and reacts with Human, Recombinant fragment - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FOXM1 aa 600-750.

View Alternative Names

FKHL16, HFH11, MPP2, WIN, FOXM1, Forkhead box protein M1, Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor from INS-1 cells, HFH-11, HNF-3/fork-head homolog 11

3 Images
Flow Cytometry - Anti-FOXM1 antibody [6F11A8] (AB234077)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-FOXM1 antibody [6F11A8] (AB234077)

Flow Cytometry analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cells, labeling FOXM1 with ab234077 at a 1/200 dilution (green) compared to a negative control (red).

Western blot - Anti-FOXM1 antibody [6F11A8] (AB234077)
  • WB

Supplier Data

Western blot - Anti-FOXM1 antibody [6F11A8] (AB234077)

Expected recombinant MW is 36.6 kDa

All lanes:

Western blot - Anti-FOXM1 antibody [6F11A8] (ab234077) at 1/100 dilution

All lanes:

Recombinant human FOXM1 (amino acids: 649-748) protein

false

Western blot - Anti-FOXM1 antibody [6F11A8] (AB234077)
  • WB

Supplier Data

Western blot - Anti-FOXM1 antibody [6F11A8] (AB234077)

All lanes:

Western blot - Anti-FOXM1 antibody [6F11A8] (ab234077) at 1/100 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) cell lysate

Lane 2:

FOXM1 (amino acids: 649-748)-hIgGFc transfected HEK-293 cell lysate

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

6F11A8

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human FOXM1 aa 600-750. The exact immunogen used to generate this antibody is proprietary information.

Q08050

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/500", "WB-species-notes": "<p></p>" }, "Recombinant fragment - Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXM1 also known as Forkhead Box M1 functions mechanically as a transcription factor. This target plays an important role in the regulation of gene expression during the cell cycle. It is characterized by a molecular weight of approximately 85 kDa. FOXM1 is mainly expressed in actively proliferating cells including the liver lungs and thymus tissues linking it with processes involved in cellular growth and division.
Biological function summary

The transcription factor FOXM1 regulates the expression of genes important for DNA replication and mitosis. It forms part of a complex network with other proteins to initiate and sustain cell proliferation. This protein regulates key regulatory genes such as Cyclin B1 and Plk1 ensuring proper transition through various phases of the cell cycle. The presence of FOXM1 in normal tissues emphasizes its role in maintaining healthy cell division.

Pathways

FOXM1 is integral to the regulation of cell cycle pathways and interacts with proteins involved in the PI3K/AKT signaling pathway. This target coordinates with various proteins to facilitate progression through cell cycle checkpoints and modulate responses to growth signals. Proteins such as CDK1 and SKP2 operate alongside FOXM1 to advance cells from G2 phase into mitosis demonstrating its involvement in cell cycle control mechanics.

FOXM1 shows significant association with cancer progression and metastasis. Overexpression of FOXM1 has been observed in colorectal and breast cancers indicating its potential as a therapeutic target. FOXM1 interacts with proteins like β-catenin in cancerous states influencing tumor growth and survival. Mutations and dysregulation of FOXM1 contribute to oncogenic processes further underlining its role in disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed : 19160488, PubMed : 20360045). Plays a role in the control of cell proliferation (PubMed : 19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed : 17101782). Promotes transcription of PHB2 (PubMed : 33754036).
See full target information FOXM1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of nanomedicine 18:5407-5422 PubMed37753068

2023

Identification and Characterization of a Novel Nanobody Against Human CTGF to Reveal Its Antifibrotic Effect in an in vitro Model of Liver Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Liu,Min Zhu,Jiaojiao Chen,Junwei Gai,Jing Huang,Yingqun Zhou,Yakun Wan,Chuantao Tu

Diabetic medicine : a journal of the British Diabetic Association 40:e15051 PubMed36692102

2023

Identification of signalling downstream of the transcription factor forkhead box protein M1 that protects against endoplasmic reticulum stress in a diabetic foot ulcer model.

Applications

Unspecified application

Species

Unspecified reactive species

Weixia Peng,Ting Zhu,Guangda Xiang,Ting Ding,Jun Zhao,Dan Xiong,Yaqin Zhong,Youqi Zhang

American journal of cancer research 12:3644-3661 PubMed36119839

2022

USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenwang Zhang,Wu Liu,Xiajun Bao,Tian Sun,Jiawei Wang,Mengxi Li,Chao Liu
View all publications
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Product promise

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