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AB264210

Anti-FOXM1 antibody

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(1 Publication)

Rabbit Polyclonal FOXM1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FOXM1 aa 450 to C-terminus.

View Alternative Names

FKHL16, HFH11, MPP2, WIN, FOXM1, Forkhead box protein M1, Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor from INS-1 cells, HFH-11, HNF-3/fork-head homolog 11

1 Images
Immunoprecipitation - Anti-FOXM1 antibody (AB264210)
  • IP

Supplier Data

Immunoprecipitation - Anti-FOXM1 antibody (AB264210)

FOXM1 was immunoprecipitated from 1mg of HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate with ab264210 at 3 μg/mg lysate. Western blot was performed from the immunoprecipitate using a different antibody was used.
Lane 1 : ab264210 IP in HeLa whole cell lysate.
Lane 2 : Control IgG.

All lanes:

Immunoprecipitation - Anti-FOXM1 antibody (ab264210)

Predicted band size: 84 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human FOXM1 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q08050

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXM1 also known as Forkhead Box M1 functions mechanically as a transcription factor. This target plays an important role in the regulation of gene expression during the cell cycle. It is characterized by a molecular weight of approximately 85 kDa. FOXM1 is mainly expressed in actively proliferating cells including the liver lungs and thymus tissues linking it with processes involved in cellular growth and division.
Biological function summary

The transcription factor FOXM1 regulates the expression of genes important for DNA replication and mitosis. It forms part of a complex network with other proteins to initiate and sustain cell proliferation. This protein regulates key regulatory genes such as Cyclin B1 and Plk1 ensuring proper transition through various phases of the cell cycle. The presence of FOXM1 in normal tissues emphasizes its role in maintaining healthy cell division.

Pathways

FOXM1 is integral to the regulation of cell cycle pathways and interacts with proteins involved in the PI3K/AKT signaling pathway. This target coordinates with various proteins to facilitate progression through cell cycle checkpoints and modulate responses to growth signals. Proteins such as CDK1 and SKP2 operate alongside FOXM1 to advance cells from G2 phase into mitosis demonstrating its involvement in cell cycle control mechanics.

FOXM1 shows significant association with cancer progression and metastasis. Overexpression of FOXM1 has been observed in colorectal and breast cancers indicating its potential as a therapeutic target. FOXM1 interacts with proteins like β-catenin in cancerous states influencing tumor growth and survival. Mutations and dysregulation of FOXM1 contribute to oncogenic processes further underlining its role in disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed : 19160488, PubMed : 20360045). Plays a role in the control of cell proliferation (PubMed : 19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed : 17101782). Promotes transcription of PHB2 (PubMed : 33754036).
See full target information FOXM1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 7:357 PubMed34785642

2021

UBE2S promotes cell chemoresistance through PTEN-AKT signaling in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Gui,Sicai Zhang,Yongzi Xu,Hongwei Zhang,Ying Zhu,Lianbao Kong
View all publications
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Product promise

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