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AB154832

Anti-Foxo6 (phospho S184) antibody [EPR6863]

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(1 Publication)

Rabbit Recombinant Monoclonal FOXO6 phospho S184 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication.

View Alternative Names

Forkhead box protein O6, FOXO6

1 Images
Western blot - Anti-Foxo6 (phospho S184) antibody [EPR6863] (AB154832)
  • WB

Unknown

Western blot - Anti-Foxo6 (phospho S184) antibody [EPR6863] (AB154832)

All lanes:

Western blot - Anti-Foxo6 (phospho S184) antibody [EPR6863] (ab154832) at 1/1000 dilution

Lane 1:

Rat brain lysate, untreated at 10 µg

Lane 2:

Rat brain lysate, treated with AP at 10 µg

Predicted band size: 61 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR6863

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Foxo6 protein also known as Forkhead box O6 is part of the Forkhead family of transcription factors characterized by a distinct forkhead DNA-binding domain. It has a molecular weight of approximately 68 kDa. Foxo6 is primarily expressed in the brain with significant presence in the hippocampus which plays an essential role in cognitive functions. Functionally Foxo6 regulates gene expression by binding to specific DNA sequences influencing various cellular processes including apoptosis metabolism and oxidative stress response.
Biological function summary

The regulatory activity of Foxo6 is important for maintaining neural integrity and proper brain function. It does not work as part of a larger complex but influences the expression of genes involved in cell cycle arrest longevity and stress resistance. Researchers have observed Foxo6 activity to affect synaptic function and plasticity in neurons which are critical for learning and memory processes. Its role in transcriptional regulation highlights its significance in managing cellular homeostasis and response to environmental changes.

Pathways

Foxo6 acts within the insulin signaling and PI3K/AKT pathways which are central to regulating growth proliferation and survival. Through these pathways Foxo6 interacts with proteins like AKT1 and 14-3-3 which modulate its activity by nuclear-cytoplasmic shuttling or degradation. The balance of Foxo6 activity within these pathways influences how cells respond to insulin and manage oxidative stress linking it to metabolic and stress response processes.

Aberrant Foxo6 activity links to neurodegenerative disorders and metabolic syndromes. In the context of Alzheimer's disease Foxo6 dysfunction may contribute to impaired cognition and synaptic deficits as its regulatory influence is important for neural health. Additionally altered Foxo6 signaling can affect insulin sensitivity relevant in conditions like type 2 diabetes as it connects through the insulin signaling pathway. These connections position Foxo6 as a potential therapeutic target for ailments associated with metabolic and cognitive impairments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional activator.
See full target information FOXO6 phospho S184
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 19:1858-1873 PubMed28564604

2017

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea E Calvert,Alexandra Chalastanis,Yongfei Wu,Lisa A Hurley,Fotini M Kouri,Yingtao Bi,Maureen Kachman,Jasmine L May,Elizabeth Bartom,Youjia Hua,Rama K Mishra,Gary E Schiltz,Oleksii Dubrovskyi,Andrew P Mazar,Marcus E Peter,Hongwu Zheng,C David James,Charles F Burant,Navdeep S Chandel,Ramana V Davuluri,Craig Horbinski,Alexander H Stegh
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com