Anti-Foxo6 (phospho S184) antibody [EPR6863] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Foxo6 protein also known as Forkhead box O6 is part of the Forkhead family of transcription factors characterized by a distinct forkhead DNA-binding domain. It has a molecular weight of approximately 68 kDa. Foxo6 is primarily expressed in the brain with significant presence in the hippocampus which plays an essential role in cognitive functions. Functionally Foxo6 regulates gene expression by binding to specific DNA sequences influencing various cellular processes including apoptosis metabolism and oxidative stress response.

Biological function summary

The regulatory activity of Foxo6 is important for maintaining neural integrity and proper brain function. It does not work as part of a larger complex but influences the expression of genes involved in cell cycle arrest longevity and stress resistance. Researchers have observed Foxo6 activity to affect synaptic function and plasticity in neurons which are critical for learning and memory processes. Its role in transcriptional regulation highlights its significance in managing cellular homeostasis and response to environmental changes.

Pathways

Foxo6 acts within the insulin signaling and PI3K/AKT pathways which are central to regulating growth proliferation and survival. Through these pathways Foxo6 interacts with proteins like AKT1 and 14-3-3 which modulate its activity by nuclear-cytoplasmic shuttling or degradation. The balance of Foxo6 activity within these pathways influences how cells respond to insulin and manage oxidative stress linking it to metabolic and stress response processes.

Associated diseases and disorders

Aberrant Foxo6 activity links to neurodegenerative disorders and metabolic syndromes. In the context of Alzheimer's disease Foxo6 dysfunction may contribute to impaired cognition and synaptic deficits as its regulatory influence is important for neural health. Additionally altered Foxo6 signaling can affect insulin sensitivity relevant in conditions like type 2 diabetes as it connects through the insulin signaling pathway. These connections position Foxo6 as a potential therapeutic target for ailments associated with metabolic and cognitive impairments.