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AB16046

Anti-FOXP2 antibody

5

(20 Reviews)

|

(220 Publications)

Anti-FOXP2 antibody (ab16046) is a rabbit polyclonal antibody detecting FOXP2 in Western Blot, IHC-P, ICC/IF. Suitable for Mouse.

- Over 170 publications
- Trusted since 2005

View Alternative Names

CAGH44, TNRC10, FOXP2, Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody (AB16046)
  • IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody (AB16046)

IHC image of FOXP2 staining in mouse e17 foetal brain formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab16046, 0.1μg/ml, for 15 mins at room temperature. A goat anti-rabbit biotinylated secondary antibody was used to detect the primary, and visualized using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Immunocytochemistry/ Immunofluorescence - Anti-FOXP2 antibody (AB16046)
  • ICC/IF

AbReview3966****

Immunocytochemistry/ Immunofluorescence - Anti-FOXP2 antibody (AB16046)

Mouse spinal cord was fixed in paraformaldehyde, blocked in 1% BSA for 30 minutes then incubated with ab16046 at 1/8000 dilution for 18 hours. This image was submitted as part of a review by Jeremy Dasen.

This image is courtesy of an abreview submitted by Jeremy Dasen.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

<p>From September 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.&nbsp;</p>

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

What is this antibody validated in?
Anti-FOXP2 antibody (ab16046) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples.

Trusted by the scientific community
Anti-FOXP2 (ab16046) was first used in a scientific publication in 2005 and has been cited over 170 times in peer-reviewed journals.

Reviewed by scientists
Anti-FOXP2 (ab16046) has over 20 independent reviews from customers.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FOXP2 gene also known as forkhead box P2 encodes a protein that plays a significant role in gene regulation. The FOXP2 protein is involved in the transcriptional regulation of its target genes acting as a transcription factor. With a molecular mass of approximately 80 kDa it binds to DNA sequences influencing the expression of other genes that control various cellular processes. FOXP2 is highly expressed in the brain particularly in regions involved in neural development and functioning such as the basal ganglia and cortex. Its presence however is also notable in specific tissues outside the central nervous system.
Biological function summary

The FOXP2 protein is essential for normal speech and language development in humans. It forms part of a transcription factor complex that controls the expression of genes involved in neural plasticity connectivity and synaptic function. This regulation is important for proper neuronal differentiation and circuit formation. Moreover FOXP2 operates in conjunction with other transcription factors highlighting its role in more extensive gene networks necessary for brain development and cognitive functions.

Pathways

FOXP2 is integrated into neural pathways impacting language and speech development. It draws connections with key signaling pathways such as the synaptic signaling pathway and Wnt signaling pathway. Within these pathways FOXP2 interacts with proteins like CNTNAP2 and SRPX2 which are instrumental in synapse development and neuron signaling. These interactions underline the importance of FOXP2 in maintaining complex signaling necessary for higher-order brain functions including those responsible for linguistic abilities.

FOXP2 mutations have strong associations with developmental verbal dyspraxia a condition affecting speech motor planning. Mutations or altered expressions in FOXP2 lead to impairments in motor-related speech processing. Additionally FOXP2 has connections with autism spectrum disorders where it might contribute to language deficits seen in affected individuals. The interaction with proteins such as CNTNAP2 which also links to language disorders showcases FOXP2's critical involvement in cognitive and speech-related pathologies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
See full target information FOXP2
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Publications (220)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113002 PubMed40703439

2025

Cellular and synaptic properties of molecularly defined neurons in the external globus pallidus.

Applications

Unspecified application

Species

Unspecified reactive species

Linda M C Koene,Wilhelm Thunberg,Sten Grillner,Gilad Silberberg,Maya Ketzef

Advanced healthcare materials 14:e04817 PubMed40702833

2025

3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Guebum Han,Nicolas S Lavoie,Nandadevi Patil,Olivia G Korenfeld,Hyunjun Kim,Manuel Esguerra,Daeha Joung,Michael C McAlpine,Ann M Parr

Nature protocols : PubMed40579542

2025

Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes.

Applications

Unspecified application

Species

Unspecified reactive species

H M Arif Ullah,Qiju Huang,Simone Chiola,Yueqi Wang,Alex Shcheglovitov

Developmental neurobiology 85:e22978 PubMed40476302

2025

Islet-2 Is Required for the Survival of Islet-Expressing Retinal Ganglion Cells but Not for Their Pathfinding to the Contralateral Dorsal Lateral Geniculate Nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Sadaf Abed,David A Feldheim

iScience 28:112456 PubMed40352729

2025

Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum regulate affect and motor control.

Applications

Unspecified application

Species

Unspecified reactive species

Johan Sköld,Gisela Paola Lazzarino,Myra Nett,Joost Wiskerke,David Engblom

Nature communications 16:3544 PubMed40229297

2025

GABAergic neurons in central amygdala contribute to orchestrating anxiety-like behaviors and breathing patterns.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyi Wang,Shangyu Bi,Ziteng Yue,Xinxin Chen,Yuhang Liu,Tianjiao Deng,Liuqi Shao,Xinyi Jing,Cuidie Wang,Yakun Wang,Wei He,Hongxiao Yu,Luo Shi,Fang Yuan,Sheng Wang

Neural regeneration research 20:2923-2937 PubMed39610105

2024

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Li,Peng Hao,Hongmei Duan,Fei Hao,Wen Zhao,Yudan Gao,Zhaoyang Yang,Kwok-Fai So,Xiaoguang Li

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2406849 PubMed39556706

2024

Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Han,Yuanlin He,Yuanhao Wang,Wenzhu Hu,Chu Chu,Lei Huang,Yuan Hong,Lu Han,Xu Zhang,Yao Gao,Yuan Lin,Hongxia Ma,Hongbing Shen,Xiaoyan Ke,Yan Liu,Zhibin Hu

Neuron 112:3602-3617.e9 PubMed39406239

2024

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Baptiste Libé-Philippot,Ryohei Iwata,Aleksandra J Recupero,Keimpe Wierda,Sergio Bernal Garcia,Luke Hammond,Anja van Benthem,Ridha Limame,Martyna Ditkowska,Sofie Beckers,Vaiva Gaspariunaite,Eugénie Peze-Heidsieck,Daan Remans,Cécile Charrier,Tom Theys,Franck Polleux,Pierre Vanderhaeghen

PLoS genetics 20:e1011428 PubMed39405291

2024

Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson-Forssman-Lehmann intellectual disability syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Helen M McRae,Melody P Y Leong,Maria I Bergamasco,Alexandra L Garnham,Yifang Hu,Mark A Corbett,Lachlan Whitehead,Farrah El-Saafin,Bilal N Sheikh,Stephen Wilcox,Anthony J Hannan,Jozef Gécz,Gordon K Smyth,Tim Thomas,Anne K Voss
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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