Anti-FOXP2 antibody (ab16046) is a rabbit polyclonal antibody that is used to detect FOXP2 in Western Blot, IHC-P, ICC/IF. Suitable for Mouse samples.
- Over 170 publications
- Trusted since 2005
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- Cellular and molecular life sciences : CMLS 80:3672023Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEned Rodríguez-Urgellés,Diana Casas-Torremocha,Anna Sancho-Balsells,Iván Ballasch,Esther García-García,Lluis Miquel-Rio,Arnau Manasanch,Ignacio Del Castillo,Wanqi Chen,Anika Pupak,Veronica Brito,Daniel Tornero,Manuel J Rodríguez,Analia Bortolozzi,Maria V Sanchez-Vives,Albert Giralt,Jordi AlberchPubMed 37987826
- Nature communications 14:74972023A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLei Tang,Nana Xu,Mengyao Huang,Wei Yi,Xuan Sang,Mingting Shao,Ye Li,Zhao-Zhe Hao,Ruifeng Liu,Yuhui Shen,Feng Yue,Xialin Liu,Chuan Xu,Sheng LiuPubMed 37980356
- Nature neuroscience 26:2131-21462023Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJulieta E Lischinsky,Luping Yin,Chenxi Shi,Nandkishore Prakash,Jared Burke,Govind Shekaran,Maria Grba,Joshua G Corbin,Dayu LinPubMed 37946049
- iScience 26:1083062023Preclinical long-term safety of intraspinal transplantation of human dorsal spinal GABA neural progenitor cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaolong Zheng,Zhixian Liu,Ziyu He,Jia Xu,YaNan Wang,ChenZi Gong,Ruoying Zhang,Su-Chun Zhang,Hong Chen,Wei WangPubMed 38026209
- Frontiers in cell and developmental biology 11:12821822023P53 independent pathogenic mechanisms contribute to BubR1 microcephaly.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNoelle A Sterling,Bethany K Terry,Julia M McDonnell,Seonhee KimPubMed 37900274
- Environmental toxicology 39:341-3562023FOXP2 suppresses the proliferation, invasion, and aerobic glycolysis of hepatocellular carcinoma cells by regulating the KDM5A/FBP1 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLijing Yan,Huanhuan Sun,Yuling Chen,Xiaohui Yu,Jingru Zhang,Peijie LiPubMed 37713600
- PLoS biology 21:e30022122023An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenny Wong,Jason A Estep,Alyssa M Treptow,Niloofar Rajabli,Jennifer N Jahncke,Teresa Ubina,Kevin M Wright,Martin M RiccomagnoPubMed 37540708
- Nature communications 14:40852023External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMatthew Baker,Seungwoo Kang,Sa-Ik Hong,Minryung Song,Minsu Abel Yang,Lee Peyton,Hesham Essa,Sang Wan Lee,Doo-Sup ChoiPubMed 37438336
- Proceedings of the National Academy of Sciences of the United States of America 120:e22170111202023Experience-dependent functional plasticity and visual response selectivity of surviving subplate neurons in the mouse visual cortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTaisuke Yoneda,Kenji Hayashi,Yumiko YoshimuraPubMed 36812195
- Nature communications 14:822023An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNoelle A Sterling,Jun Young Park,Raehee Park,Seo-Hee Cho,Seonhee KimPubMed 36604424
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Not recommended | Not recommended | Not recommended |
| Mouse | Expected | Tested | Expected |
| Rat | Not recommended | Not recommended | Predicted |
WB
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000 | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Rat | Dilution info - | Notes - |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
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Target data
Function
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
Alternative names
CAGH44, TNRC10, FOXP2, Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein
Recommended products
Anti-FOXP2 antibody (ab16046) is a rabbit polyclonal antibody that is used to detect FOXP2 in Western Blot, IHC-P, ICC/IF. Suitable for Mouse samples.
- Over 170 publications
- Trusted since 2005
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Specificity
From September 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-FOXP2 antibody (ab16046) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples.
Trusted by the scientific community
Anti-FOXP2 (ab16046) was first used in a scientific publication in 2005 and has been cited over 170 times in peer-reviewed journals.
Reviewed by scientists
Anti-FOXP2 (ab16046) has over 20 independent reviews from customers.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The FOXP2 gene also known as forkhead box P2 encodes a protein that plays a significant role in gene regulation. The FOXP2 protein is involved in the transcriptional regulation of its target genes acting as a transcription factor. With a molecular mass of approximately 80 kDa it binds to DNA sequences influencing the expression of other genes that control various cellular processes. FOXP2 is highly expressed in the brain particularly in regions involved in neural development and functioning such as the basal ganglia and cortex. Its presence however is also notable in specific tissues outside the central nervous system.
- Biological function summary
The FOXP2 protein is essential for normal speech and language development in humans. It forms part of a transcription factor complex that controls the expression of genes involved in neural plasticity connectivity and synaptic function. This regulation is important for proper neuronal differentiation and circuit formation. Moreover FOXP2 operates in conjunction with other transcription factors highlighting its role in more extensive gene networks necessary for brain development and cognitive functions.
- Pathways
FOXP2 is integrated into neural pathways impacting language and speech development. It draws connections with key signaling pathways such as the synaptic signaling pathway and Wnt signaling pathway. Within these pathways FOXP2 interacts with proteins like CNTNAP2 and SRPX2 which are instrumental in synapse development and neuron signaling. These interactions underline the importance of FOXP2 in maintaining complex signaling necessary for higher-order brain functions including those responsible for linguistic abilities.
- Associated diseases and disorders
FOXP2 mutations have strong associations with developmental verbal dyspraxia a condition affecting speech motor planning. Mutations or altered expressions in FOXP2 lead to impairments in motor-related speech processing. Additionally FOXP2 has connections with autism spectrum disorders where it might contribute to language deficits seen in affected individuals. The interaction with proteins such as CNTNAP2 which also links to language disorders showcases FOXP2's critical involvement in cognitive and speech-related pathologies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody (ab16046)
IHC image of FOXP2 staining in mouse e17 foetal brain formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab16046, 0.1μg/ml, for 15 mins at room temperature. A goat anti-rabbit biotinylated secondary antibody was used to detect the primary, and visualized using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
This image is courtesy of a customer review submitted by Jeremy Dasen.Immunocytochemistry/ Immunofluorescence - Anti-FOXP2 antibody (ab16046)
Mouse spinal cord was fixed in paraformaldehyde, blocked in 1% BSA for 30 minutes then incubated with ab16046 at 1/8000 dilution for 18 hours. This image was submitted as part of a review by Jeremy Dasen.
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