Anti-FOXP2 antibody [CL5312]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The FOXP2 gene also known as forkhead box P2 encodes a protein that plays a significant role in gene regulation. The FOXP2 protein is involved in the transcriptional regulation of its target genes acting as a transcription factor. With a molecular mass of approximately 80 kDa it binds to DNA sequences influencing the expression of other genes that control various cellular processes. FOXP2 is highly expressed in the brain particularly in regions involved in neural development and functioning such as the basal ganglia and cortex. Its presence however is also notable in specific tissues outside the central nervous system.

Biological function summary

The FOXP2 protein is essential for normal speech and language development in humans. It forms part of a transcription factor complex that controls the expression of genes involved in neural plasticity connectivity and synaptic function. This regulation is important for proper neuronal differentiation and circuit formation. Moreover FOXP2 operates in conjunction with other transcription factors highlighting its role in more extensive gene networks necessary for brain development and cognitive functions.

Pathways

FOXP2 is integrated into neural pathways impacting language and speech development. It draws connections with key signaling pathways such as the synaptic signaling pathway and Wnt signaling pathway. Within these pathways FOXP2 interacts with proteins like CNTNAP2 and SRPX2 which are instrumental in synapse development and neuron signaling. These interactions underline the importance of FOXP2 in maintaining complex signaling necessary for higher-order brain functions including those responsible for linguistic abilities.

Associated diseases and disorders

FOXP2 mutations have strong associations with developmental verbal dyspraxia a condition affecting speech motor planning. Mutations or altered expressions in FOXP2 lead to impairments in motor-related speech processing. Additionally FOXP2 has connections with autism spectrum disorders where it might contribute to language deficits seen in affected individuals. The interaction with proteins such as CNTNAP2 which also links to language disorders showcases FOXP2's critical involvement in cognitive and speech-related pathologies.