AB243038

Anti-FOXP2 antibody [CL5312]

Name: Anti-FOXP2 antibody [CL5312] (ab243038) | Abcam
Brand: Abcam Limited
SKU: AB243038
Price: 630 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal FOXP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXP2 aa 200-350.

View Alternative Names

CAGH44, TNRC10, FOXP2, Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein

8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Paraffin-embedded human cerebral cortex tissue stained for FOXP2 with ab243038 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-FOXP2 antibody [CL5312] (AB243038)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FOXP2 antibody [CL5312] (AB243038)

PFA-fixed, Triton X-100 permeabilized RH-30 cells stained for FOXP2 (green) using ab243038 at 2-10 μg/ml in ICC/IF. Microtubules are shown in red.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Negative control :

Paraffin-embedded human lymph node tissue stained for FOXP2 with ab243038 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Paraffin-embedded human cerebral cortex tissue stained for FOXP2 with ab243038 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Paraffin-embedded mouse cerebral cortex tissue stained for FOXP2 with ab243038 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Paraffin-embedded rat cerebral cortex tissue stained for FOXP2 with ab243038 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Paraffin-embedded mouse brain tissue stained for FOXP2 with ab243038 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Paraffin-embedded rat brain tissue stained for FOXP2 with ab243038 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CL5312

Isotype

IgG1

Carrier free

Reacts with

Mouse, Rat, Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FOXP2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

O15409

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "2-10 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Purified from TCS.

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FOXP2 gene also known as forkhead box P2 encodes a protein that plays a significant role in gene regulation. The FOXP2 protein is involved in the transcriptional regulation of its target genes acting as a transcription factor. With a molecular mass of approximately 80 kDa it binds to DNA sequences influencing the expression of other genes that control various cellular processes. FOXP2 is highly expressed in the brain particularly in regions involved in neural development and functioning such as the basal ganglia and cortex. Its presence however is also notable in specific tissues outside the central nervous system.

Biological function summary

The FOXP2 protein is essential for normal speech and language development in humans. It forms part of a transcription factor complex that controls the expression of genes involved in neural plasticity connectivity and synaptic function. This regulation is important for proper neuronal differentiation and circuit formation. Moreover FOXP2 operates in conjunction with other transcription factors highlighting its role in more extensive gene networks necessary for brain development and cognitive functions.

Pathways

FOXP2 is integrated into neural pathways impacting language and speech development. It draws connections with key signaling pathways such as the synaptic signaling pathway and Wnt signaling pathway. Within these pathways FOXP2 interacts with proteins like CNTNAP2 and SRPX2 which are instrumental in synapse development and neuron signaling. These interactions underline the importance of FOXP2 in maintaining complex signaling necessary for higher-order brain functions including those responsible for linguistic abilities.

FOXP2 mutations have strong associations with developmental verbal dyspraxia a condition affecting speech motor planning. Mutations or altered expressions in FOXP2 lead to impairments in motor-related speech processing. Additionally FOXP2 has connections with autism spectrum disorders where it might contribute to language deficits seen in affected individuals. The interaction with proteins such as CNTNAP2 which also links to language disorders showcases FOXP2's critical involvement in cognitive and speech-related pathologies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

See full target information FOXP2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature 598:205-213 PubMed34616060

2021

Single-cell epigenomics reveals mechanisms of human cortical development.

Applications

Unspecified application

Species

Unspecified reactive species

Ryan S Ziffra,Chang N Kim,Jayden M Ross,Amy Wilfert,Tychele N Turner,Maximilian Haeussler,Alex M Casella,Pawel F Przytycki,Kathleen C Keough,David Shin,Derek Bogdanoff,Anat Kreimer,Katherine S Pollard,Seth A Ament,Evan E Eichler,Nadav Ahituv,Tomasz J Nowakowski

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FOXP2 antibody [CL5312]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Immunocytochemistry/ Immunofluorescence - Anti-FOXP2 antibody [CL5312] (AB243038)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody [CL5312] (AB243038)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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