Rabbit Polyclonal FOXP3 antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Mouse Foxp3 aa 200-250.
IgG
Rabbit
Preservative: 0.02% Sodium azide
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Predicted | Predicted |
Mouse | Expected | Tested |
Rat | Tested | Tested |
Cat | Predicted | Predicted |
Cow | Predicted | Predicted |
Cynomolgus monkey | Predicted | Predicted |
Deer | Predicted | Predicted |
Monkey | Predicted | Predicted |
Pig | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Rat | Dilution info 1/500 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Cow, Cat, Human, Pig, Monkey, Cynomolgus monkey, Deer | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 1/100 | Notes - |
Species Rat | Dilution info 1/100 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Cow, Cat, Human, Pig, Monkey, Cynomolgus monkey, Deer | Dilution info - | Notes - |
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Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:22813742). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (PubMed:19696312).
Forkhead box protein P3, Scurfin, Foxp3
Rabbit Polyclonal FOXP3 antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Mouse Foxp3 aa 200-250.
IgG
Rabbit
Preservative: 0.02% Sodium azide
Liquid
Polyclonal
Affinity purification Protein A
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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Immunofluorescence of tumors from mice treated with MN-siPDL1 and gemcitabine. There was evidence of an increase in cell-mediated cytotoxicity, as evidenced by a decrease in the infiltration by immunosuppressive Foxp3 + regulatory T (Treg) cells detected using ab75763.
This image has been cropped from the origanal figure.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Mouse kidney tissue staining FOXP3 using ab75763 at 1/100. DAB staining (brown) Hematoxylin QS counterstain (blue).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Mouse kidney tissue staining FOXP3 using ab75763 at 1/100. DAB staining (brown) Hematoxylin QS counterstain (blue).
All lanes: Western blot - Anti-FOXP3 antibody (ab75763) at 1/500 dilution
Lane 1: rat kidney lysate
Lane 2: rat cerebral cortex lysate
Predicted band size: 47 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Rat kidney tissue staining FOXP3 using ab75763 at 1/100. DAB staining (brown) Hematoxylin QS counterstain (blue).
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