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AB251688

Anti-FOXP4 antibody

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(3 Publications)

Rabbit Polyclonal FOXP4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FOXP4 aa 550 to C-terminus.

View Alternative Names

FKHLA, FOXP4, Forkhead box protein P4, Fork head-related protein-like A

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-FOXP4 antibody (AB251688)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FOXP4 antibody (AB251688)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for FOXP4 (green) using ab251688 at 4 µg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP4 antibody (AB251688)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP4 antibody (AB251688)

Paraffin-embedded human stomach tissue stained for FOXP4 using ab251688 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-FOXP4 antibody (AB251688)
  • WB

Unknown

Western blot - Anti-FOXP4 antibody (AB251688)

All lanes:

Western blot - Anti-FOXP4 antibody (ab251688) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) lysate

Lane 2:

FOXP4 overexpression HEK-293T cell lysate

Predicted band size: 73 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FOXP4 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IVH2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXP4 also known as Forkhead Box P4 is a transcription factor belonging to the FOX protein family. Its molecular mass approximately 80 kDa. It is expressed in various tissues with high expression levels observed in lung kidney and prostate. The protein binds to DNA and regulates the transcription of genes involved in development and differentiation.
Biological function summary

FOXP4 plays an important role in regulating developmental processes particularly in the central nervous system and lung tissue. It often functions as part of a complex that includes other FOXP proteins like FOXP1 and FOXP2 which share a conserved DNA-binding forkhead domain. These proteins collaborate to regulate genes important for cell differentiation and organogenesis.

Pathways

The transcriptional activity of FOXP4 integrates into significant signaling pathways such as the Wnt signaling and TGF-beta pathways. These pathways govern processes like cellular growth and differentiation. FOXP4 interacts with other FOX proteins including FOXP1 to modulate gene expression patterns important for these pathways.

Research indicates that FOXP4 is associated with lung cancer and neurodevelopmental disorders. Its dysregulation can affect cellular processes linked to tumorigenesis and cognitive development. FOXP4’s involvement with other proteins such as FOXP1 highlights its role in modulating gene networks that when disrupted can contribute to disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional repressor that represses lung-specific expression.
See full target information FOXP4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Hereditas 162:15 PubMed39901302

2025

Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Senhui Wei,Ying Li,Jing Zhou,Yongming Xia

Thoracic cancer 12:372-381 PubMed33350095

2020

Exosomal miR-3180-3p inhibits proliferation and metastasis of non-small cell lung cancer by downregulating FOXP4.

Applications

Unspecified application

Species

Unspecified reactive species

Tengfei Chen,Yali Liu,Jun Chen,Huifei Zheng,Qiuyun Chen,Jun Zhao

Cell death & disease 10:472 PubMed31209207

2019

LncRNA FOXP4-AS1 is activated by PAX5 and promotes the growth of prostate cancer by sequestering miR-3184-5p to upregulate FOXP4.

Applications

Unspecified application

Species

Unspecified reactive species

Xingcheng Wu,Yu Xiao,Yi Zhou,Zhien Zhou,Weigang Yan
View all publications
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Product promise

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