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Rabbit Polyclonal FOXR2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXR2 aa 100 to C-terminus.

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Images

Western blot - Anti-FOXR2 antibody (AB151476), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human FOXR2 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6PJQ5

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Associated Products

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1 product for Alternative Product

Alternative names

Recommended products

Rabbit Polyclonal FOXR2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXR2 aa 100 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human FOXR2 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6PJQ5
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FOXR2 also known as Forkhead box protein R2 is a transcription factor with a mass of approximately 31 kDa. It is part of the large family of forkhead transcription factors characterized by a distinct DNA-binding domain known as the "forkhead box". FOXR2 expression is mostly observed in the brain particularly within the central nervous system. Researchers have identified its expression in other tissues under specific conditions indicating a potential role beyond its primary locations.

Biological function summary

FOXR2 influences gene regulation processes involved in cellular growth and differentiation. It does not seem to form large complexes but may interact with other transcription factors or co-regulators to fulfill its functional roles. Its regulatory functions highlight its impact on the development and maintenance of neuronal structures. Evidence suggests that FOXR2 may also participate in controlling cellular metabolism linking it to pathways that manage bioenergetics within the cells.

Pathways

FOXR2 has roles in important developmental pathways and cell cycle regulation. It modulates the Hedgehog signaling pathway a pathway significant in embryonic development and tissue regeneration. FOXR2 works alongside proteins like GLI1 to mediate transcriptional responses. Although not directly involved FOXR2 influences the Wnt signaling pathway which controls cellular proliferation and differentiation aligning its function with proteins such as β-catenin.

Associated diseases and disorders

FOXR2 has associations with specific cancers particularly brain tumors like gliomas and neuroblastoma. Overexpression or mutations in FOXR2 can disrupt normal cellular growth leading to tumorigenesis. Studies have shown a connection between FOXR2 and MYC a well-known oncogene in the context of tumor progression. Additionally schizophrenia has correlations with aberrant FOXR2 expression linking it indirectly to proteins involved in neurodevelopment such as DISC1. Understanding these associations opens potential for developing therapies targeting FOXR2-related pathways.

Product promise

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1 product image

  • Western blot - Anti-FOXR2 antibody (ab151476), expandable thumbnail

    Western blot - Anti-FOXR2 antibody (ab151476)

    All lanes: Western blot - Anti-FOXR2 antibody (ab151476) at 1/500 dilution

    All lanes: Raji whole cell lysate at 30 µg/mL

    Predicted band size: 36 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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