Rabbit Polyclonal FOXR2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXR2 aa 100 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Select an associated product type
FOXN6, FOXR2, Forkhead box protein R2, Forkhead box protein N6
Rabbit Polyclonal FOXR2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXR2 aa 100 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
FOXR2 also known as Forkhead box protein R2 is a transcription factor with a mass of approximately 31 kDa. It is part of the large family of forkhead transcription factors characterized by a distinct DNA-binding domain known as the "forkhead box". FOXR2 expression is mostly observed in the brain particularly within the central nervous system. Researchers have identified its expression in other tissues under specific conditions indicating a potential role beyond its primary locations.
FOXR2 influences gene regulation processes involved in cellular growth and differentiation. It does not seem to form large complexes but may interact with other transcription factors or co-regulators to fulfill its functional roles. Its regulatory functions highlight its impact on the development and maintenance of neuronal structures. Evidence suggests that FOXR2 may also participate in controlling cellular metabolism linking it to pathways that manage bioenergetics within the cells.
FOXR2 has roles in important developmental pathways and cell cycle regulation. It modulates the Hedgehog signaling pathway a pathway significant in embryonic development and tissue regeneration. FOXR2 works alongside proteins like GLI1 to mediate transcriptional responses. Although not directly involved FOXR2 influences the Wnt signaling pathway which controls cellular proliferation and differentiation aligning its function with proteins such as β-catenin.
FOXR2 has associations with specific cancers particularly brain tumors like gliomas and neuroblastoma. Overexpression or mutations in FOXR2 can disrupt normal cellular growth leading to tumorigenesis. Studies have shown a connection between FOXR2 and MYC a well-known oncogene in the context of tumor progression. Additionally schizophrenia has correlations with aberrant FOXR2 expression linking it indirectly to proteins involved in neurodevelopment such as DISC1. Understanding these associations opens potential for developing therapies targeting FOXR2-related pathways.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Terms & Conditions.
All lanes: Western blot - Anti-FOXR2 antibody (ab151476) at 1/500 dilution
All lanes: Raji whole cell lysate at 30 µg/mL
Predicted band size: 36 kDa
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