AB244513

Anti-FOXR2 antibody

Name: Anti-FOXR2 antibody (ab244513) | Abcam
Brand: Abcam Limited
SKU: AB244513
Price: 635 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal FOXR2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FOXR2 aa 1-100.

View Alternative Names

FOXN6, FOXR2, Forkhead box protein R2, Forkhead box protein N6

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-FOXR2 antibody (AB244513)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FOXR2 antibody (AB244513)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for FOXR2 (green) using ab244513 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXR2 antibody (AB244513)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXR2 antibody (AB244513)

Paraffin-embedded human placenta tissue stained for FOXR2 using ab244513 at 1/2500 dilution in immunohistochemical analysis.

Unknown

Western blot - Anti-FOXR2 antibody (AB244513)

All lanes:

Western blot - Anti-FOXR2 antibody (ab244513) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate

Lane 2:

FOXR2 (with C-terminal myc-DDK tag) overexpresed in HEK-293T, cell lysate

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FOXR2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q6PJQ5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/2500 - 1/5000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXR2 also known as Forkhead box protein R2 is a transcription factor with a mass of approximately 31 kDa. It is part of the large family of forkhead transcription factors characterized by a distinct DNA-binding domain known as the "forkhead box". FOXR2 expression is mostly observed in the brain particularly within the central nervous system. Researchers have identified its expression in other tissues under specific conditions indicating a potential role beyond its primary locations.

Biological function summary

FOXR2 influences gene regulation processes involved in cellular growth and differentiation. It does not seem to form large complexes but may interact with other transcription factors or co-regulators to fulfill its functional roles. Its regulatory functions highlight its impact on the development and maintenance of neuronal structures. Evidence suggests that FOXR2 may also participate in controlling cellular metabolism linking it to pathways that manage bioenergetics within the cells.

Pathways

FOXR2 has roles in important developmental pathways and cell cycle regulation. It modulates the Hedgehog signaling pathway a pathway significant in embryonic development and tissue regeneration. FOXR2 works alongside proteins like GLI1 to mediate transcriptional responses. Although not directly involved FOXR2 influences the Wnt signaling pathway which controls cellular proliferation and differentiation aligning its function with proteins such as β-catenin.

FOXR2 has associations with specific cancers particularly brain tumors like gliomas and neuroblastoma. Overexpression or mutations in FOXR2 can disrupt normal cellular growth leading to tumorigenesis. Studies have shown a connection between FOXR2 and MYC a well-known oncogene in the context of tumor progression. Additionally schizophrenia has correlations with aberrant FOXR2 expression linking it indirectly to proteins involved in neurodevelopment such as DISC1. Understanding these associations opens potential for developing therapies targeting FOXR2-related pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information FOXR2

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:4647 PubMed40442086

2025

High resolution clonal architecture of hypomutated Wilms tumours.

Applications

Unspecified application

Species

Unspecified reactive species

Henry Lee-Six,Taryn D Treger,Manas Dave,Tim Hh Coorens,Nathaniel D Anderson,Yvonne Tiersma,Sepide Derakhshan,Sanne de Haan,Marry M van den Heuvel-Eibrink,Yichen Wang,Anna Wenger,Reem Al-Saadi,Alice Lawford,Aleksandra Letunovska,Jenny Wegert,Conor Parks,Guillaume Morcrette,Manfred Gessler,Gordan Vujanic,Tanzina Chowdhury,Maureen J O'Sullivan,Ronald R de Krijger,Michael R Stratton,Kathy Pritchard-Jones,J Ciaran Hutchinson,Jarno Drost,Sam Behjati

Viruses 17: PubMed40431628

2025

The COPII Transport Complex Participates in HPV16 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia M Day,Cynthia D Thompson,Andrea S Weisberg,John T Schiller

Molecular therapy. Nucleic acids 19:718-730 PubMed31945729

2020

circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252.

Applications

Unspecified application

Species

Unspecified reactive species

Shu Zhang,Jie Cheng,Chenlian Quan,Hao Wen,Zheng Feng,Qin Hu,Jun Zhu,Yan Huang,Xiaohua Wu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FOXR2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-FOXR2 antibody (AB244513)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXR2 antibody (AB244513)

Western blot - Anti-FOXR2 antibody (AB244513)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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