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AB181185

Anti-FP100 antibody [EPR13721]

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(1 Publication)

Rabbit Recombinant Monoclonal FP100 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

C17orf70, FAAP100, Fanconi anemia core complex-associated protein 100, Fanconi anemia-associated protein of 100 kDa

1 Images
Western blot - Anti-FP100 antibody [EPR13721] (AB181185)
  • WB

Supplier Data

Western blot - Anti-FP100 antibody [EPR13721] (AB181185)

All lanes:

Western blot - Anti-FP100 antibody [EPR13721] (ab181185) at 1/1000 dilution

Lane 1:

Hela cell lysate at 20 µg

Lane 2:

Jurkat cell lysate at 20 µg

Lane 3:

HepG2 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 93 kDa

Observed band size: 93 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13721

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FP100 also known by some researchers as Protein Zeta has a molecular mass of approximately 50 kDa. It is an intracellular protein that can be found mostly in the cytoplasm of immune cells including macrophages and dendritic cells. The protein serves as an adapter that interacts with multiple signaling molecules. By doing this it helps facilitate the assembly of protein complexes that are essential for downstream signal transmission.
Biological function summary

This protein enables efficient immune cell communication in response to external stimuli. FP100 acts as a scaffold in forming complexes that promote signaling pathways important for immune response activation. It interacts with kinases and phosphatases to regulate signal transduction processes that are responsible for initiating cell activation proliferation and survival.

Pathways

FP100 is an important participant in the NF-kB and MAPK signaling pathways. These pathways play an important role in mediating inflammatory responses and cell survival. FP100 connects with proteins like IKK-beta in the NF-kB pathway and MEK1/2 in the MAPK pathway assisting in modulating responses to infections or cellular stress.

Variations or dysregulation of FP100 activity relate closely to autoimmune conditions and chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Its interaction with proteins like TNF-alpha and interleukin-6 places FP100 at a strategic position influencing the pathological progression of these disorders making it a potential therapeutic target for intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed.
See full target information FAAP100
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:106417 PubMed37153444

2023

Ultra-rare complement factor 8 coding variants in families with age-related macular degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Lina Zelinger,Tammy M Martin,Jayshree Advani,Laura Campello,Milton A English,Alan Kwong,Claire Weber,Jennifer Maykoski,Yuri V Sergeev,Robert Fariss,Emily Y Chew,Michael L Klein,Anand Swaroop
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com