AB113531

Anti-FPR1 antibody

Name: Anti-FPR1 antibody (ab113531) | Abcam
Brand: Abcam Limited
SKU: AB113531
Price: 495 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(16 Publications)

Rabbit Polyclonal FPR1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human fMet-Leu-Phe receptor conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, N-formylpeptide chemoattractant receptor, FPR, FPR1

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FPR1 antibody (AB113531)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FPR1 antibody (AB113531)

ab113531 at 5ug/ml staining FPR1 in Formalin-Fixed, Paraffin-Embedded Human spleen tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-FPR1 antibody (AB113531)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FPR1 antibody (AB113531)

ab113531 at a 1/100 dilution staining FPR1 in Human MCF7 cells by Immunofluorescence. The cells on the right were incubated with the immunizing peptide.

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Western blot - Anti-FPR1 antibody (AB113531)

All lanes:

Western blot - Anti-FPR1 antibody (ab113531) at 1/500 dilution

Lane 1:

K562 cell extract

Lane 2:

K562 cell extract with immunizing peptide

Predicted band size: 38 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human fMet-Leu-Phe receptor conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P21462

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FPR1 also known as fMet-Leu-Phe receptor (fMLP receptor) is a G-protein coupled receptor with a molecular mass of approximately 38 kDa. It primarily expresses on the surface of myeloid cells like neutrophils monocytes and macrophages. FPR1 mediates responses to chemotactic factors guiding immune cells to sites of infection or inflammation by detecting formyl peptides from bacterial and mitochondrial origins.

Biological function summary

FPR1 plays an important role in initiating and regulating innate immune responses. It is not part of a complex but functions through association with G-proteins which activate intracellular signaling cascades. Its activation leads to rapid cellular responses such as chemotaxis superoxide production and degranulation which are essential for effective pathogen clearance by the immune system.

Pathways

FPR1 involvement in chemotaxis and MAP kinase signaling highlights its importance in immune surveillance. It integrates signals from bacteria-derived formylated peptides linking the external chemotactic cues to the internal migratory response of leukocytes. Other proteins like the chemokine CXC receptor family operate in complementary pathways to FPR1 collectively orchestrating immune trafficking and activation.

Defective FPR1 function is implicated in chronic inflammatory conditions and impaired host defense mechanisms such as systemic lupus erythematosus (SLE) and certain bacterial infections. In SLE altered FPR1 activity disrupts normal immune response contributing to disease persistence. FPR1's interaction with proteins like CD14 further highlights its role in modulating inflammatory responses relevant to these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed : 10514456, PubMed : 15153520, PubMed : 2161213, PubMed : 2176894). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed : 15153520, PubMed : 15210802, PubMed : 1712023, PubMed : 2161213). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed : 10514456, PubMed : 1712023). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed : 25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed : 15210802).

See full target information fMet-Leu-Phe receptor

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

Cell biology and toxicology 41:97 PubMed40483281

2025

Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hongwei Jiang,Lirun Kuang,Tianyi Zhang,Xupeng Zhao

RSC medicinal chemistry 16:1397-1409 PubMed39886349

2025

Development of small-molecule fluorescent probes targeting neutrophils -formyl peptide receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Xu,Kalwant S Authi,Liliya N Kirpotina,Igor A Schepetkin,Mark T Quinn,Agostino Cilibrizzi

Cell research 33:585-603 PubMed37337030

2023

An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Wu,Jiayan Yan,Yinqi Bai,Feiyu Chen,Xuanxuan Zou,Jiangshan Xu,Ao Huang,Liangzhen Hou,Yu Zhong,Zehua Jing,Qichao Yu,Xiaorui Zhou,Zhifeng Jiang,Chunqing Wang,Mengnan Cheng,Yuan Ji,Yingyong Hou,Rongkui Luo,Qinqin Li,Liang Wu,Jianwen Cheng,Pengxiang Wang,Dezhen Guo,Waidong Huang,Junjie Lei,Shang Liu,Yizhen Yan,Yiling Chen,Sha Liao,Yuxiang Li,Haixiang Sun,Na Yao,Xiangyu Zhang,Shiyu Zhang,Xi Chen,Yang Yu,Yao Li,Fengming Liu,Zheng Wang,Shaolai Zhou,Huanming Yang,Shuang Yang,Xun Xu,Longqi Liu,Qiang Gao,Zhaoyou Tang,Xiangdong Wang,Jian Wang,Jia Fan,Shiping Liu,Xinrong Yang,Ao Chen,Jian Zhou

Nature immunology 23:518-531 PubMed35354953

2022

Neutrophils direct preexisting matrix to initiate repair in damaged tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Adrian Fischer,Juliane Wannemacher,Simon Christ,Tim Koopmans,Safwen Kadri,Jiakuan Zhao,Mahesh Gouda,Haifeng Ye,Martin Mück-Häusl,Peter W Krenn,Hans-Günther Machens,Reinhard Fässler,Philipp-Alexander Neumann,Stefanie M Hauck,Yuval Rinkevich

Frontiers in pharmacology 12:696697 PubMed34393780

2021

The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.

Applications

Unspecified application

Species

Unspecified reactive species

Chaolu Chen,Shuaiying Zhu,Long Bai,Meihua Sui,Danqing Chen

Annals of translational medicine 8:1174 PubMed33241023

2020

Inhibition of formyl peptide receptor 1 activity suppresses tumorigenicity and attenuates the invasion and migration of lung adenocarcinoma cells under hypoxic conditions .

Applications

Unspecified application

Species

Unspecified reactive species

Bo Huang,Hongrong Guo,Jie Ding,Jun Li,Hongjuan Wang,Jianqun Xu,Quan Zheng,Lijun Zhou,Qin Dai

Cells 9: PubMed33255171

2020

New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Gorrasi,Anna Maria Petrone,Anna Li Santi,Mariaevelina Alfieri,Nunzia Montuori,Pia Ragno

Journal of the American Heart Association 9:e017820 PubMed33225820

2020

Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel J Tyrrell,Muriel G Blin,Jianrui Song,Sherri C Wood,Daniel R Goldstein

Respirology (Carlton, Vic.) 26:233-240 PubMed33078507

2020

Acute cigarette smoke-induced eQTL affects formyl peptide receptor expression and lung function.

Applications

Unspecified application

Species

Unspecified reactive species

Simon D Pouwels,Valerie R Wiersma,Immeke E Fokkema,Marijn Berg,Nick H T Ten Hacken,Maarten van den Berge,Irene Heijink,Alen Faiz

Scientific reports 10:17249 PubMed33057069

2020

Application of small molecule FPR1 antagonists in the treatment of cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Djevdet S Ahmet,Haneen A Basheer,Anwar Salem,Di Lu,Amin Aghamohammadi,Patrick Weyerhäuser,Andrea Bordiga,Juman Almeniawi,Sabah Rashid,Patricia A Cooper,Steven D Shnyder,Victoria Vinader,Kamyar Afarinkia

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FPR1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FPR1 antibody (AB113531)

Immunocytochemistry/ Immunofluorescence - Anti-FPR1 antibody (AB113531)

Western blot - Anti-FPR1 antibody (AB113531)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (16)

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Primary Antibodies

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