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AB216838

Anti-FRA2 antibody

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(1 Publication)

Rabbit Polyclonal FRA2 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FOSL2 aa 250 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

FRA2, FOSL2, Fos-related antigen 2, FRA-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRA2 antibody (AB216838)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRA2 antibody (AB216838)

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling FRA2 with ab216838 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRA2 antibody (AB216838)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRA2 antibody (AB216838)

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded mouse lymphoma tissue labeling FRA2 with ab216838 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human FOSL2 aa 250 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P15408

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FRA2 also known as FOSL2 is a member of the activator protein-1 (AP-1) transcription factor family. It exhibits a molecular mass of approximately 35 kDa. This protein shows expression in various tissues including epithelial and immune cells. FRA2 functions by forming heterodimers with Jun family members influencing gene transcription regulation by binding to DNA at specific AP-1 sites.
Biological function summary

FRA2 plays a significant role in cellular processes such as differentiation proliferation and apoptosis. It is an integral part of the AP-1 transcription factor complex which regulates the expression of genes linked to cell cycle and stress responses. FRA2 impacts extracellular matrix production and remodeling highlighting its involvement in tissue development and repair.

Pathways

FRA2 participates in the MAPK signaling pathway an important cascade influencing cell fate decisions. Through this pathway it interacts with proteins like MAPK and ERK which facilitate the transmission of signals from receptors on the cell surface to the DNA in the nucleus. FRA2's participation in the TGF-beta pathway also highlights its role in regulating gene expression associated with growth and differentiation.

FRA2 links to conditions such as cancer and pulmonary fibrosis. It interacts with proteins like Smad3 and Smad4 in the context of cancer progression where it can influence tumor growth and metastasis. In pulmonary fibrosis FRA2 influences fibroblast activation and collagen production contributing to the pathological tissue remodeling seen in the disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).
See full target information FOSL2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 14:45 PubMed36941658

2023

BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Nan Xu,Wen Xu,Xu Zhang,Dan-Yang Wang,Xin-Rui Zheng,Wei Liu,Jia-Mei Chen,Gao-Feng Chen,Cheng-Hai Liu,Ping Liu,Yong-Ping Mu
View all publications
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Product promise

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