Rabbit Polyclonal FREM1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FREM1 conjugated to Keyhole Limpet Haemocyanin.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FREM1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q5H8C1
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Target data
Function
Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.
Alternative names
C9orf143, C9orf145, C9orf154, FREM1, FRAS1-related extracellular matrix protein 1, Protein QBRICK
Recommended products
Rabbit Polyclonal FREM1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FREM1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FREM1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q5H8C1
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 12 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FREM1 also known as Fras1-related extracellular matrix protein 1 serves mechanical roles by interacting with the extracellular matrix. This protein has a mass of approximately 230 kDa. It is prominently expressed in skin kidney and lung tissues. FREM1's interactions contribute to the structural stability and organization of tissues aiding their resilience and function.
- Biological function summary
FREM1 plays a critical role in skin and organ development. It is an important part of the Fraser complex which is essential during the formation of epithelial and basement membranes. The protein's function supports cellular adhesion and proper tissue morphogenesis. These roles are necessary for maintaining tissue integrity making it well-integrated into developmental processes.
- Pathways
FREM1 integrates with developmental signaling cascades essential to epithelial integrity and tissue cohesion. Notably it participates in the Wnt signaling pathway which is fundamental for cell fate determination. Through these pathways FREM1 coordinates with other proteins like FRAS1 and FREM2 ensuring proper signaling and communication within cell environments.
- Associated diseases and disorders
FREM1 mutations and disruptions relate to Fraser syndrome which involves congenital malformations affecting the eyes ears and skin. FREM1's interaction with FRAS1 and FREM2 is critical in this context as these proteins form the Fraser complex. Additionally irregularities in FREM1 expression may relate to kidney dysplasia highlighting its role in normal organ morphogenesis and function.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FREM1 antibody (ab117566)
ab117566, at 10 µg/ml, staining FREM1 in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.
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