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AB117612

Anti-FREM2 antibody

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(1 Publication)

Rabbit Polyclonal FREM2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FREM2 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

FRAS1-related extracellular matrix protein 2, ECM3 homolog, FREM2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FREM2 antibody (AB117612)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FREM2 antibody (AB117612)

ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human breast tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FREM2 antibody (AB117612)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FREM2 antibody (AB117612)

ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human FREM2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q5SZK8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FREM2 (Fras-related extracellular matrix 2) is a protein involved in cell-matrix interactions. It plays a mechanical role by contributing to the stability and structure of extracellular matrices. The FREM2 protein is predominantly expressed in the developing kidney and skin. It is also predominantly found in the basement membranes where it functions as part of the skin's mechanical framework. The molecular weight of the FREM2 protein is approximately 330 kDa reflecting its large and complex structure. Alternative names include TILRR and Truncated Interleukin-1 Receptor-Associated Kinase 1.
Biological function summary

FREM2 plays a significant role in embryonic development and tissue integrity. It forms part of a complex that includes extracellular matrix proteins such as FRAS1 and FREM1 which are critical for proper epidermal-dermal adhesion. The protein interacts with these partners to maintain the strength and flexibility of skin and renal tissues. FREM2 is essential during the development of multiple organ systems which highlights its importance in establishing connective tissues.

Pathways

FREM2 involves itself in pathways dedicated to skin morphogenesis and kidney development. In the skin morphogenesis pathway FREM2 interacts with proteins such as the peroxisome proliferator-activated receptor gamma (PPARG) which influences lipid metabolism and inflammatory responses important for skin barrier function. The protein interacts with other molecules in renal morphogenesis pathways maintaining the adhesion necessary for kidney structuring though it does not share direct pathway intersections with some more recognized proteins like nephrin.

FREM2’s dysfunction relates closely to Fraser syndrome and other congenital malformations. Mutations or aberrations in FREM2 can disrupt normal extracellular matrix interactions leading to these conditions. Fraser syndrome for instance is characterized by cryptophthalmos syndactyly and renal defects. The disease associations of FREM2 often involve proteins like FRAS1 which similarly impacts extracellular matrix stability and can exacerbate developmental anomalies when mutated.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (PubMed : 15838507). Required for epidermal adhesion (PubMed : 15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed : 29688405, PubMed : 30802441).
See full target information FREM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 224: PubMed40304687

2025

Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuki Isogai,Koichiro M Hirosawa,Miki Kanno,Ayano Sho,Rinshi S Kasai,Naoko Komura,Hiromune Ando,Keiko Furukawa,Yuhsuke Ohmi,Koichi Furukawa,Yasunari Yokota,Kenichi G N Suzuki
View all publications
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Product promise

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