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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal Frizzled 8 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FZD8.
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Mouse | Predicted |
Rat | Predicted |
Common marmoset | Predicted |
Cow | Predicted |
Dog | Predicted |
Elephant | Predicted |
Lizard | Predicted |
Opossum | Predicted |
Rabbit | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 8.00000-20.00000 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Rabbit, Cow, Dog, Lizard, Opossum, Common marmoset, Elephant | Dilution info - | Notes - |
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Frizzled-8, Fz-8, hFz8, FZD8
Rabbit Polyclonal Frizzled 8 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FZD8.
Frizzled-8, Fz-8, hFz8, FZD8
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except INTS6 (50%).
Blue Ice
-20°C
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
FZD8 influences cellular communication within the Wnt signaling pathway impacting processes like cell proliferation and fate determination. FZD8 often associates with other proteins in complex formations particularly when assembling with Wnt ligands on the cell surface. It plays an important role in embryonic development and tissue homeostasis where precise cellular signaling is necessary for maintaining the balance between cell growth and programmed cell death.
Frizzled 8 also known as FZD8 forms part of the Frizzled family of proteins which serve as receptors for the Wnt signaling pathway. This protein with a mass of approximately 70 kDa contains a characteristic cysteine-rich domain. FZD8 mainly localizes to the cell membrane and prominently expresses in tissues such as the brain heart and placenta. Its structure includes seven transmembrane domains which contributes significantly to its role in signal transduction.
FZD8 interacts most prominently within the canonical Wnt/β-catenin signaling pathway. It works closely with the Dishevelled (DVL) protein facilitating signal transfer from the cell surface to the cytoplasm and beyond. This involvement tightly links FZD8 to many developmental processes and cellular communication networks. Additionally FZD8 is also implicated in the non-canonical Wnt pathways demonstrating its versatility in various cellular signaling contexts.
FZD8 is associated with conditions such as cancer and neurodegenerative diseases. Dysregulation of FZD8 may contribute to abnormal cell proliferation as observed in certain cancers when improper Wnt signaling causes uncontrolled cellular growth. Additionally its connection with Alzheimer's disease highlights the importance of FZD8 in neuronal maintenance and function. Abberations in FZD8 or its signaling partners such as β-catenin may lead to pathogenesis in these diseases.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cerebellum purkinje neurons labelling Frizzled 8 with ab150500 at 20 µg/ml.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human fetal kidney tissue labelling Frizzled 8 with ab150500 at 20 µg/ml.
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