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AB61430

Anti-Frizzled 9 antibody

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(3 Publications)

Rabbit Polyclonal Frizzled 9 antibody. Suitable for IHC-FoFr, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FZD9 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CD349, FZD3, FZD9, Frizzled-9, Fz-9, hFz9, FzE6

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Frizzled 9 antibody (AB61430)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Frizzled 9 antibody (AB61430)

ab61430, at 10μg/ml, staining human Frizzled 9 in testis, using Immunohistochemistry, Formalin/PFA fixed Paraffin embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

IHC-FoFr, IHC-P

applications

Immunogen

Synthetic Peptide within Human FZD9 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O00144

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.7 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Frizzled 9 also known as FZD9 or the frizzled class receptor 9 acts as a receptor for Wnt proteins. This protein is a member of the Frizzled family involved in the Wnt signaling pathway. Frizzled 9 has an approximate mass of 67 kDa. Researchers have found that it expresses in various tissues particularly in the brain lungs and bone. Its expression pattern indicates a role in both development and disease processes.
Biological function summary

Frizzled class receptor 9 functions in cellular communication and development. It does not operate alone but often forms complexes with co-receptors like LDL receptor-related protein 5/6 (LRP5/6). Through these complexes it transmits signals important for various cellular functions such as proliferation differentiation and migration. Frizzled 9’s signaling affects cellular processes contributing significantly to maintaining normal cellular homeostasis.

Pathways

Frizzled receptor 9 participates in the Wnt/β-catenin signaling and the planar cell polarity (PCP) pathway. In the Wnt/β-catenin pathway frizzled 9 interacts with proteins such as β-catenin and Dishevelled (Dvl) leading to gene expression changes. In the PCP pathway frizzled 9 contributes to the regulation of cellular orientation within tissues. Through these pathways frizzled 9 plays a role in cell fate determination and tissue patterning making it an important component in organismal development and disease.

Alterations in frizzled 9 function link to osteoporosis and cancer. Its expression levels and signaling efficiency can impact bone density connecting it to LRP5/6 in osteoporosis. Abnormal frizzled 9 signaling may also influence cancer development as disruptions in the Wnt pathway are known to affect cell proliferation and tumor growth. Understanding frizzled 9’s interplay with these proteins provides insight into its role in disease mechanisms and potential therapeutic implications.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed : 27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).
See full target information FZD9
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 11:560074 PubMed33304345

2020

M1 Polarization Markers Are Upregulated in Basal-Like Breast Cancer Molecular Subtype and Associated With Favorable Patient Outcome.

Applications

Unspecified application

Species

Unspecified reactive species

Mahmood Yaseen Hachim,Ibrahim Yaseen Hachim,Iman M Talaat,Nada M Yakout,Rifat Hamoudi

Cellular and molecular life sciences : CMLS 77:4631-4662 PubMed31900623

2020

Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord.

Applications

Unspecified application

Species

Unspecified reactive species

Pau González,Carlos González-Fernández,Yolanda Campos-Martín,Manuela Mollejo,Melissa Carballosa-Gautam,Alexander Marcillo,Michael Norenberg,Francisco Javier Rodríguez

PloS one 7:e50793 PubMed23251385

2012

Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats.

Applications

IHC-P

Species

Rat

Pau Gonzalez,Carmen Maria Fernandez-Martos,Carlos Gonzalez-Fernandez,Ernest Arenas,Francisco Javier Rodriguez
View all publications
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