AB108628

Anti-Frizzled 9 antibody [EPR4011]

RabMAb
Recombinant
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(3 Publications)

Rabbit Recombinant Monoclonal Frizzled 9 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications.

View Alternative Names

CD349, FZD3, FZD9, Frizzled-9, Fz-9, hFz9, FzE6

1 Images

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Western blot - Anti-Frizzled 9 antibody [EPR4011] (AB108628)

All lanes:

Western blot - Anti-Frizzled 9 antibody [EPR4011] (ab108628) at 1/1000 dilution

Lane 1:

Human Seminoma lysate at 10 µg

Lane 2:

Human fetal kidney lysate at 10 µg

Lane 3:

Human fetal testis lysate at 10 µg

Predicted band size: 64 kDa

Observed band size: 65 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4011

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Frizzled 9 also known as FZD9 or the frizzled class receptor 9 acts as a receptor for Wnt proteins. This protein is a member of the Frizzled family involved in the Wnt signaling pathway. Frizzled 9 has an approximate mass of 67 kDa. Researchers have found that it expresses in various tissues particularly in the brain lungs and bone. Its expression pattern indicates a role in both development and disease processes.

Biological function summary

Frizzled class receptor 9 functions in cellular communication and development. It does not operate alone but often forms complexes with co-receptors like LDL receptor-related protein 5/6 (LRP5/6). Through these complexes it transmits signals important for various cellular functions such as proliferation differentiation and migration. Frizzled 9’s signaling affects cellular processes contributing significantly to maintaining normal cellular homeostasis.

Pathways

Frizzled receptor 9 participates in the Wnt/β-catenin signaling and the planar cell polarity (PCP) pathway. In the Wnt/β-catenin pathway frizzled 9 interacts with proteins such as β-catenin and Dishevelled (Dvl) leading to gene expression changes. In the PCP pathway frizzled 9 contributes to the regulation of cellular orientation within tissues. Through these pathways frizzled 9 plays a role in cell fate determination and tissue patterning making it an important component in organismal development and disease.

Alterations in frizzled 9 function link to osteoporosis and cancer. Its expression levels and signaling efficiency can impact bone density connecting it to LRP5/6 in osteoporosis. Abnormal frizzled 9 signaling may also influence cancer development as disruptions in the Wnt pathway are known to affect cell proliferation and tumor growth. Understanding frizzled 9’s interplay with these proteins provides insight into its role in disease mechanisms and potential therapeutic implications.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed : 27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).

See full target information FZD9

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Open life sciences 18:20220711 PubMed37671092

2023

TRIM29 knockdown prevented the colon cancer progression through decreasing the ubiquitination levels of KRT5.

Applications

Unspecified application

Species

Unspecified reactive species

Lihui Sun,Dawei Wang,Zhenyu Chen,Xu Zhu

mSphere 6: PubMed33883266

2021

Ehrlichia chaffeensis TRP120 Is a Wnt Ligand Mimetic That Interacts with Wnt Receptors and Contains a Novel Repetitive Short Linear Motif That Activates Wnt Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Madison R Rogan,LaNisha L Patterson,Caitlan D Byerly,Tian Luo,Slobodan Paessler,Veljko Veljkovic,Bethany Quade,Jere W McBride

iScience 15:391-406 PubMed31108394

2019

Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip.

Applications

Unspecified application

Species

Unspecified reactive species

Woojung Shin,Christopher D Hinojosa,Donald E Ingber,Hyun Jung Kim

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Frizzled 9 antibody [EPR4011]

Western blot - Anti-Frizzled 9 antibody [EPR4011] (AB108628)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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