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AB91623

Anti-FRK antibody [4E1]

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(1 Publication)

Mouse Monoclonal FRK antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRK.

View Alternative Names

PTK5, RAK, FRK, Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5

1 Images
Western blot - Anti-FRK antibody [4E1] (AB91623)
  • WB

Unknown

Western blot - Anti-FRK antibody [4E1] (AB91623)

All lanes:

Western blot - Anti-FRK antibody [4E1] (ab91623) at 1/500 dilution

All lanes:

K562 cell lysate

Predicted band size: 58 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4E1

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human FRK. The exact immunogen used to generate this antibody is proprietary information.

P42685

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FRK also known as FYN-related kinase or RAK is a non-receptor tyrosine kinase with a molecular mass of approximately 56 kDa. This protein is predominantly expressed in epithelial tissues including those of the breast kidney and liver. FRK displays substrate specificity and catalytic function by phosphorylating specific tyrosine residues on target proteins which influences cellular processes such as proliferation and differentiation.
Biological function summary

This kinase contributes to the regulation of cell cycle progression and apoptosis. FRK acts solo as well as part of larger signal transduction complexes. It plays a vital role in limiting uncontrolled cellular growth which is particularly significant in maintaining tissue homeostasis. FRK regulates various molecular interactions essential for cell adhesion and communication adding another layer of control over cell physiology.

Pathways

FRK integrates into signaling pathways like the PI3K/AKT and MAPK pathways. These pathways are critical for mediating responses to growth signals and stress conditions. FRK's activity modulates protein interactions with key molecules such as p53 and PTEN influencing downstream effects that control cell cycle checkpoints and apoptosis. By interacting with these pathways FRK helps to balance cell proliferation and survival in response to extracellular cues.

FRK has implications in cancer development particularly in breast cancer. Altered FRK expression or activity has been associated with tumor progression and resistance to treatment. FRK interacts with proteins such as BRCA1 contributing to its role in DNA damage response and tumor suppression. Additionally FRK's aberrant activity links to certain forms of renal disorders where it impacts cellular responses in renal tissue often through modulation of E-cadherin and β-catenin in epithelial cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
See full target information FRK
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 87:7367-81 PubMed23616652

2013

The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Melissanne de Wispelaere,Amy J LaCroix,Priscilla L Yang
View all publications
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Product promise

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