Rabbit Polyclonal FRMD8 antibody. Suitable for WB and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human FRMD8 aa 200-450.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human FRMD8 aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BZ67
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).
Alternative names
FKSG44, FRMD8, FERM domain-containing protein 8, Band4.1 inhibitor LRP interactor, iRhom tail-associated protein, Bili, iTAP
Recommended products
Rabbit Polyclonal FRMD8 antibody. Suitable for WB and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human FRMD8 aa 200-450.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human FRMD8 aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BZ67
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FRMD8 also known as FERM domain-containing protein 8 has an approximate molecular mass of 76 kDa. This protein belongs to the FERM domain protein family characterized by having domains linked to cytoskeletal arrangements and membrane interactions. It expresses in various human tissues including the brain and the liver suggesting it performs functions necessary in multiple systems. It plays a structural or signaling role linked to its FERM domain capabilities.
- Biological function summary
FRMD8 plays an essential role in cellular signaling and structure. It interacts with CYTH3 a protein significant for intracellular signaling and cytoskeletal dynamics. By interacting with proteins that regulate actin cytoskeleton FRMD8 helps maintain cellular architecture and motility. FRMD8 may also participate in protein complexes that influence cellular morphology and signaling cascades.
- Pathways
FRMD8 engages in essential cellular pathways such as actin polymerization and Rho GTPase-mediated signaling. These pathways are important for cell shape migration and division. FRMD8 interacts with members of the Rho GTPase family like Rac1 further linking it to actin cytoskeletal rearrangements. In this way FRMD8 influences cellular behaviors that depend on cytoskeletal dynamics and intracellular communication.
- Associated diseases and disorders
FRMD8 associates with certain cancers and neurological conditions. In cancer it may interact with proteins like TKT that influence tumor cell metabolism and survival. Regarding neurological disorders the connection with proteins such as Alpha-synuclein links FRMD8 to synaptic function regulation and aggregation processes implicated in neurodegenerative diseases. This budding research area suggests that FRMD8 plays a significant role in disease biological mechanisms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-FRMD8 antibody (ab127745)
10% SDS PAGE
All lanes: Western blot - Anti-FRMD8 antibody (ab127745) at 1/500 dilution
All lanes: NIH 3T3 whole cell lysate at 30 µg
Predicted band size: 51 kDa
Western blot - Anti-FRMD8 antibody (ab127745)
10% SDS PAGE
All lanes: Western blot - Anti-FRMD8 antibody (ab127745) at 1/500 dilution
Lane 1: HeLa whole cell lysate at 30 µg
Lane 2: HepG2 whole cell lysate at 30 µg
Predicted band size: 51 kDa
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