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AB113420

Anti-FRMPD4 antibody

3

(1 Review)

|

(1 Publication)

Rabbit Polyclonal FRMPD4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FRMPD4 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

KIAA0316, PDZD10, PDZK10, FRMPD4, FERM and PDZ domain-containing protein 4, PDZ domain-containing protein 10, PSD-95-interacting regulator of spine morphogenesis, Preso

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRMPD4 antibody (AB113420)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRMPD4 antibody (AB113420)

ab113420 at 5 μg/ml staining FRMPD4 in Human kidney by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Western blot - Anti-FRMPD4 antibody (AB113420)
  • WB

Unknown

Western blot - Anti-FRMPD4 antibody (AB113420)

Lane 1:

Western blot - Anti-FRMPD4 antibody (ab113420) at 1 µg/mL

Lane 2:

Western blot - Anti-FRMPD4 antibody (ab113420) at 2 µg/mL

All lanes:

SK N SH cell lysate

Predicted band size: 144 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human FRMPD4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q14CM0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FRMPD4 also known as FERM and PDZ domain containing 4 is a protein that is involved in the formation of cellular junctions. It weighs approximately 134 kDa. This protein shows expression in the brain kidney and heart with higher levels particularly in the cerebral cortex. FRMPD4 has a significant role in normal neuronal functioning. The PDZ domains in FRMPD4 enable interaction with the membrane-associated proteins and scaffold its integration to specific cell parts.
Biological function summary

FRMPD4 plays a role in synaptic communication and signal transduction. It participates as a component of a multi-protein complex which is essential for maintaining synaptic integrity and proper neuronal signaling. This complex involvement helps facilitate communication between neurons and supports synaptic plasticity which is critical for learning and memory functions.

Pathways

This protein is integral in synaptic plasticity and cell adhesion pathways. FRMPD4 interacts with proteins such as GRIP1 involved in glutamate receptor trafficking during synaptic function and facilitates receptor stability and localization. The presence of FRMPD4 in these pathways ensures that neurons respond correctly to synaptic inputs and maintain proper communication with adjacent cells.

Alterations in FRMPD4 expression or function associate with autism spectrum disorders (ASD) and intellectual disability. FRMPD4 abnormalities could disturb its interaction with GRIP1 influencing synaptic signaling and cognitive abilities. The potential link of this protein with these disorders suggests that it might serve as a target for therapeutic interventions aimed at correcting the synaptic dysfunction underlying these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.
See full target information FRMPD4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Atherosclerosis 254:133-141 PubMed27741419

2016

Endophilin-A2-mediated increase in scavenger receptor expression contributes to macrophage-derived foam cell formation.

Applications

Unspecified application

Species

Unspecified reactive species

Er-Wen Huang,Can-Zhao Liu,Si-Jia Liang,Zheng Zhang,Xiao-Fei Lv,Jie Liu,Jia-Guo Zhou,Yong-Bo Tang,Yong-Yuan Guan
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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