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AB150876

Anti-FRY antibody

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(1 Publication)

Rabbit Polyclonal FRY antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRY aa 650-750.

View Alternative Names

C13orf14, FRY, Protein furry homolog

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human kidney tissue labeling FRY in the cytoplasm of cells in tubules with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human endometrium tissue labeling FRY in the cytoplasm of glandular cells with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human heart muscle tissue labeling FRY in the cytoplasm of myocytes with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human gastrointestinal tissue labeling FRY in the cytoplasm of glandular cells with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FRY aa 650-750. The exact immunogen used to generate this antibody is proprietary information.

Q5TBA9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FRY also known as furry homolog or protein fetal andadults-1 is a protein with an approximate mass of 240 kDa. It plays a critical mechanical role in cellular processes by interacting with microtubules which are structures that assist with cell division and shape maintenance. FRY is expressed widely in tissues but shows particularly high levels in the brain liver and lungs indicating its importance in various organ functions. Researchers also notice influence on gene regulation owing to its role in transcriptional activities.
Biological function summary

FRY contributes to diverse cell activities beyond mechanical support. This protein is part of a complex contributing to cell polarity and mitosis essential for proper cell orientation and division. An important function includes its participation in the organization of mitotic spindles structures needed during cell division to evenly separate chromosomes. Given these functions FRY maintains cell structure integrity and supports proper DNA segregation among daughter cells during mitosis.

Pathways

FRY connects to pivotal cellular pathways such as the cell cycle regulation and spindle assembly pathways. It interacts closely with proteins like Aurora kinase B which is vital for correct chromosome alignment and segregation. FRY’s role within these pathways ensures smooth transitions between different cell cycle stages. This integration shows its multifaceted influence in both central and supporting roles concerning cellular dynamics.

Mutations and abnormalities in FRY expression associate with brain-related conditions including glioma and other neurodevelopmental disorders. Research indicates FRY's linkage to cancer development through its interaction with tumor suppressor proteins like p53 which plays a prominent role in cell cycle arrest and apoptosis. These connections suggest FRY's potential as a target for novel disease treatments and better understanding could lead to advances in therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
See full target information FRY
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:106559 PubMed37123228

2023

Multiomic landscape of immune pathogenesis in Kimura's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xunyao Wu,Anqi Wang,Sumei Zhang,Xiaoxi Wang,Dan Guo,Weiguo Zhu,Yang Jiao,Jiaxin Zhou,Wen Zhang,Linyi Peng,Minghui Duan,Yunyun Fei
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Product promise

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