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Rabbit Polyclonal FSH-R antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human FSHR aa 250-350.


Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human FSHR aa 250-350. The exact immunogen used to generate this antibody is proprietary information. Database link P23945
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PICC/IF
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

10 µg/mL

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/500.00000

Notes

-

Target data

Function

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).

Alternative names

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Rabbit Polyclonal FSH-R antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human FSHR aa 250-350.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen

Synthetic Peptide within Human FSHR aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Database link P23945

Purification technique

Affinity purification Protein A

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Supplementary info

Biological summary

FSH-R facilitates the growth and maturation of ovarian follicles in females and supports spermatogenesis in males. It does not function as part of a larger protein complex but interacts with various G-proteins to trigger downstream signaling. The activation of FSH-R promotes the production of sex steroids and gamete development directly influencing fertility and reproductive success. The receptor’s function is critical during the reproductive cycle regulating the development of the gametes.

Mechanical summary

FSH-R also known as FSH receptor or follicle-stimulating hormone receptor has a molecular mass of approximately 78 kDa. It is mainly expressed in the gonadal tissues including ovarian granulosa cells in females and Sertoli cells in males. This receptor is part of the G-protein coupled receptor family and plays an important role in mediating the actions of the follicle-stimulating hormone (FSH) which is important for reproductive processes. Additionally other alternative names include follitropin receptor.

Pathway

The interaction of FSH-R with G-proteins activates the cyclic adenosine monophosphate (cAMP) signaling pathway an important regulator of cellular hormone responses. This pathway impacts the expression of genes related to steroidogenesis and follicular development. FSH-R signaling also shows linkage to the MAPK pathway which further influences cellular proliferation and differentiation. In these pathways FSH-R works closely with proteins like aromatase and LH receptor highlighting its regulation of endocrine functions.

Disease

FSH-R plays a significant role in infertility and ovarian hyperstimulation syndrome (OHSS). Mutations or malfunctions within the FSH-R can lead to irregularities in FSH signaling affecting fertility by impairing gamete production or hormonal balance. Among these disrupted pathways cross-talk with the LH receptor and dysregulated cAMP signaling are common highlighting FSH-R's involvement in these reproductive conditions. Proper functioning of the FSH-R is essential to maintain normal reproductive health and prevent these disorders.

Product promise

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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FSH-R antibody (ab113421), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FSH-R antibody (ab113421)

    ab113421 at 10 μg/ml staining FSH-R in Human ovary by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

  • Immunocytochemistry/ Immunofluorescence - Anti-FSH-R antibody (ab113421), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-FSH-R antibody (ab113421)

    Immunofluorescence analysis of MCF7 cells, using ab113421 at 1/100 dilution. The image on the right is treated with the synthesized peptide.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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