AB113421

Anti-FSH-R antibody

Name: Anti-FSH-R antibody (ab113421) | Abcam
Brand: Abcam Limited
SKU: AB113421
Rating: 3 (3 reviews)

(3 Reviews)

(15 Publications)

Rabbit Polyclonal FSH-R antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human FSHR aa 250-350.

View Alternative Names

LGR1, FSHR, Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-FSH-R antibody (AB113421)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FSH-R antibody (AB113421)

Immunofluorescence analysis of MCF7 cells, using ab113421 at 1/100 dilution. The image on the right is treated with the synthesized peptide.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FSH-R antibody (AB113421)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FSH-R antibody (AB113421)

ab113421 at 10 μg/ml staining FSH-R in Human ovary by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human FSHR aa 250-350. The exact immunogen used to generate this antibody is proprietary information.

P23945

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FSH-R also known as FSH receptor or follicle-stimulating hormone receptor has a molecular mass of approximately 78 kDa. It is mainly expressed in the gonadal tissues including ovarian granulosa cells in females and Sertoli cells in males. This receptor is part of the G-protein coupled receptor family and plays an important role in mediating the actions of the follicle-stimulating hormone (FSH) which is important for reproductive processes. Additionally other alternative names include follitropin receptor.

Biological function summary

FSH-R facilitates the growth and maturation of ovarian follicles in females and supports spermatogenesis in males. It does not function as part of a larger protein complex but interacts with various G-proteins to trigger downstream signaling. The activation of FSH-R promotes the production of sex steroids and gamete development directly influencing fertility and reproductive success. The receptor’s function is critical during the reproductive cycle regulating the development of the gametes.

Pathways

The interaction of FSH-R with G-proteins activates the cyclic adenosine monophosphate (cAMP) signaling pathway an important regulator of cellular hormone responses. This pathway impacts the expression of genes related to steroidogenesis and follicular development. FSH-R signaling also shows linkage to the MAPK pathway which further influences cellular proliferation and differentiation. In these pathways FSH-R works closely with proteins like aromatase and LH receptor highlighting its regulation of endocrine functions.

FSH-R plays a significant role in infertility and ovarian hyperstimulation syndrome (OHSS). Mutations or malfunctions within the FSH-R can lead to irregularities in FSH signaling affecting fertility by impairing gamete production or hormonal balance. Among these disrupted pathways cross-talk with the LH receptor and dysregulated cAMP signaling are common highlighting FSH-R's involvement in these reproductive conditions. Proper functioning of the FSH-R is essential to maintain normal reproductive health and prevent these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed : 11847099, PubMed : 24058690, PubMed : 24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed : 24058690).

See full target information FSHR

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Journal of ovarian research 17:224 PubMed39543679

2024

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles harboring IGF-1 improve ovarian function of mice with premature ovarian insufficiency through the Nrf2/HO-1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Miao,Congxiu Miao,Na Li,Jing Han

Journal of animal science and biotechnology 15:119 PubMed39232832

2024

Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hongwei Duan,Fang Wang,Ke Wang,Shuai Yang,Rong Zhang,Chen Xue,Lihong Zhang,Xiaofei Ma,Xianghong Du,Jian Kang,Yong Zhang,Xingxu Zhao,Junjie Hu,Longfei Xiao

Frontiers in endocrinology 14:1095031 PubMed36875462

2023

Inadequate detection of the FSHR complicates future research on extragonadal FSHR localization.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria N Tedjawirja,Gerrit K J Hooijer,C Dilara Savci-Heijink,Kristina Kovac,Ron Balm,Vivian de Waard

Journal of ovarian research 15:129 PubMed36476625

2022

Luteinizing hormone stimulates the expression of amphiregulin in human theca cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Liu,Yiping Zhong,Xiaoting Shen,Xi Guo,Rihan Wu,Turui Yang,Minghui Chen

International journal of environmental research and public health 19: PubMed36430063

2022

Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer and .

Applications

Unspecified application

Species

Unspecified reactive species

Shuman Sheng,Wei Liu,Yafei Xue,Zhengwu Pan,Lanlan Zhao,Fei Wang,Xiaoyi Qi

International journal of molecular sciences 23: PubMed35955699

2022

MicroRNA-7a2 Contributes to Estrogen Synthesis and Is Modulated by FSH via the JNK Signaling Pathway in Ovarian Granulosa Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Liuhui Li,Jinglin Zhang,Chenyang Lu,Bingjie Wang,Jiajia Guo,Haitong Zhang,Sheng Cui

Journal of ovarian research 15:42 PubMed35392972

2022

Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Huiying Li,Tianli Chang,Hongbei Mu,Wenpei Xiang

Journal of ovarian research 15:30 PubMed35227296

2022

Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Zou,Yukun Li,Nianchun Liao,Jue Liu,Qunfeng Zhang,Min Luo,Jiao Xiao,Yanhua Chen,Mengjie Wang,Kexin Chen,Juan Zeng,Zhongcheng Mo

International journal of biological sciences 18:1008-1021 PubMed35173533

2022

Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Huiying Li,Xiaofei Wang,Hongbei Mu,Qiaojuan Mei,Yu Liu,Zou Min,Ling Zhang,Ping Su,Wenpei Xiang

Nature communications 12:5827 PubMed34625553

2021

Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment.

Applications

Unspecified application

Species

Unspecified reactive species

Wu Zuo,Guangming Chen,Zhimei Gao,Shuai Li,Yanyan Chen,Chenhui Huang,Juan Chen,Zhengjun Chen,Ming Lei,Qian Bian

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FSH-R antibody

Immunocytochemistry/ Immunofluorescence - Anti-FSH-R antibody (AB113421)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FSH-R antibody (AB113421)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (15)

Product promise