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AB75200

Anti-FSH-R antibody

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(16 Publications)

Rabbit Polyclonal FSH-R antibody. Suitable for WB and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human FSHR.

View Alternative Names

LGR1, FSHR, Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor

1 Images
Western blot - Anti-FSH-R antibody (AB75200)
  • WB

Unknown

Western blot - Anti-FSH-R antibody (AB75200)

All lanes:

Western blot - Anti-FSH-R antibody (ab75200) at 1/500 dilution

Lane 1:

Transfected Jurkat cell extract at 10 µg

Lane 2:

Transfected HUVEC cell extract at 10 µg

Lane 3:

Transfected Jurkat cell extract at 10 µg with immunising peptide

Predicted band size: 78 kDa

Observed band size: 78 kDa,85 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FSHR. The exact immunogen used to generate this antibody is proprietary information.

P23945

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FSH-R also known as FSH receptor or follicle-stimulating hormone receptor has a molecular mass of approximately 78 kDa. It is mainly expressed in the gonadal tissues including ovarian granulosa cells in females and Sertoli cells in males. This receptor is part of the G-protein coupled receptor family and plays an important role in mediating the actions of the follicle-stimulating hormone (FSH) which is important for reproductive processes. Additionally other alternative names include follitropin receptor.
Biological function summary

FSH-R facilitates the growth and maturation of ovarian follicles in females and supports spermatogenesis in males. It does not function as part of a larger protein complex but interacts with various G-proteins to trigger downstream signaling. The activation of FSH-R promotes the production of sex steroids and gamete development directly influencing fertility and reproductive success. The receptor’s function is critical during the reproductive cycle regulating the development of the gametes.

Pathways

The interaction of FSH-R with G-proteins activates the cyclic adenosine monophosphate (cAMP) signaling pathway an important regulator of cellular hormone responses. This pathway impacts the expression of genes related to steroidogenesis and follicular development. FSH-R signaling also shows linkage to the MAPK pathway which further influences cellular proliferation and differentiation. In these pathways FSH-R works closely with proteins like aromatase and LH receptor highlighting its regulation of endocrine functions.

FSH-R plays a significant role in infertility and ovarian hyperstimulation syndrome (OHSS). Mutations or malfunctions within the FSH-R can lead to irregularities in FSH signaling affecting fertility by impairing gamete production or hormonal balance. Among these disrupted pathways cross-talk with the LH receptor and dysregulated cAMP signaling are common highlighting FSH-R's involvement in these reproductive conditions. Proper functioning of the FSH-R is essential to maintain normal reproductive health and prevent these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed : 11847099, PubMed : 24058690, PubMed : 24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed : 24058690).
See full target information FSHR
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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:6991 PubMed37914684

2023

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Cheng,Hong Zhu,Jun Ren,Hai-Yan Wu,Jia-En Yu,Lu-Yang Jin,Hai-Yan Pang,Hai-Tao Pan,Si-Si Luo,Jing Yan,Kai-Xuan Dong,Long-Yun Ye,Cheng-Liang Zhou,Jie-Xue Pan,Zhuo-Xian Meng,Ting Yu,Li Jin,Xian-Hua Lin,Yan-Ting Wu,Hong-Bo Yang,Xin-Mei Liu,Jian-Zhong Sheng,Guo-Lian Ding,He-Feng Huang

Molecular medicine reports 28: PubMed37732532

2023

Alteration of relative telomere length and telomerase reverse transcriptase expression in the granulosa cells of women during aging and assessment of fertilization outcomes.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Hao,Mingrong Lv,Jing Peng,Dan Kuang,Zhihua Zhang,Zhou Zhang,Tingting Wang,Bo Yang,Zhaolian Wei,Ping Zhou,Zhiguo Zhang,Yunxia Cao

Frontiers in endocrinology 14:1095031 PubMed36875462

2023

Inadequate detection of the FSHR complicates future research on extragonadal FSHR localization.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria N Tedjawirja,Gerrit K J Hooijer,C Dilara Savci-Heijink,Kristina Kovac,Ron Balm,Vivian de Waard

Journal of vascular research 59:358-368 PubMed36412620

2022

Follicle-Stimulating Hormone Accelerates Atherosclerosis by Activating PI3K/Akt/NF-κB Pathway in Mice with Androgen Deprivation.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyu Piao,Yifan Yin,Yaru Zhao,Yi Han,Huixia Zhan,Duosheng Luo,Jiao Guo

International journal of environmental research and public health 19: PubMed36430063

2022

Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer and .

Applications

Unspecified application

Species

Unspecified reactive species

Shuman Sheng,Wei Liu,Yafei Xue,Zhengwu Pan,Lanlan Zhao,Fei Wang,Xiaoyi Qi

International journal of molecular sciences 22: PubMed34681919

2021

Effect of Exogenous Melatonin on the Development of Mice Ovarian Follicles and Follicular Angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Jingli Tao,Liangliang Zhang,Xuan Zhang,Yuanyuan Chen,Qianqian Chen,Ming Shen,Honglin Liu,Shoulong Deng

Stem cell research & therapy 12:517 PubMed34579781

2021

Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nesrine Ebrahim,Hajir A Al Saihati,Amani Shaman,Arigue A Dessouky,Ayman Samir Farid,Noha I Hussien,Ola Mostafa,Yasmin Seleem,Dina Sabry,Ahmed S Saad,Hanan Tawfeek Emam,Amira Hassouna,Omnia A M Badr,Bayan A Saffaf,Nicholas R Forsyth,Rabab F Salim

Pharmaceutics 12: PubMed33105674

2020

Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier.

Applications

Unspecified application

Species

Unspecified reactive species

Raymond K Hau,Siennah R Miller,Stephen H Wright,Nathan J Cherrington

Animals : an open access journal from MDPI 9: PubMed31683864

2019

Leptin Receptor Mediates Bmal1 Regulation of Estrogen Synthesis in Granulosa Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Guiyan Chu,Guangjun Ma,Jingchun Sun,Youbo Zhu,Aoqi Xiang,Gongshe Yang,Shiduo Sun

Cell death & disease 10:811 PubMed31649264

2019

ACTL6A regulates follicle-stimulating hormone-driven glycolysis in ovarian cancer cells via PGK1.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawen Zhang,Jing Zhang,Yingze Wei,Qingxian Li,Qingying Wang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
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3

(3 reviews)

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