Goat Polyclonal FSTL1/FRP antibody. Suitable for WB and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human FSTL1 aa 250 to C-terminus.
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- Physiological reports 10:e153002022Aerobic exercise training-induced follistatin-like 1 secretion in the skeletal muscle is related to arterial stiffness via arterial NO production in obese rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKenichiro Inoue,Shumpei Fujie,Naoki Horii,Henry Yamazaki,Masataka Uchida,Motoyuki IemitsuPubMed 35585770
- American journal of cancer research 11:4981-49932021HuR enhances FSTL1 transcript stability to promote invasion and metastasis of squamous cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGopinath M Sundaram,Shan Quah,Lum Guo Guang,Prabha SampathPubMed 34765305
- Aging 13:11455-114692021Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-κB axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHua Cao,Xinsheng Han,Yonglin Jia,Baohua ZhangPubMed 33839699
- Genome biology 22:542021A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Li et. al.PubMed 33514403
- Oxidative medicine and cellular longevity 2020:35987152020Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYintao Zhao et. al.PubMed 32831995
- The Journal of experimental medicine 214:2889-29002017EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGopinath M Sundaram et. al.PubMed 28827448
- Placenta 36:1231-82015The expression and post-transcriptional regulation of FSTL1 transcripts in placental trophoblasts.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJean-Francois Mouillet,Takuya Mishima,Andrea Mollica do Amarante Paffaro,Tony W Parks,Judy A Ziegler,Tianjiao Chu,Yoel SadovskyPubMed 26386648
- Nature 495:103-62013'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGopinath M Sundaram et. al.PubMed 23395958
- American journal of physiology. Renal physiology 299:F1320-72010Follistatin-like 1 regulates renal IL-1β expression in cisplatin nephrotoxicity.
- Journal of proteome research 9:6-212009Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B.Applications:WBReactive species:HumanAstrid Slany,Verena J Haudek,Hannes Zwickl,Nina C Gundacker,Michael Grusch,Thomas S Weiss,Katja Seir,Chantal Rodgarkia-Dara,Claus Hellerbrand,Christopher GernerPubMed 19678649
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FSTL1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q12841
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Cow | Predicted |
| Cynomolgus monkey | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes A 1 hour primary incubation is recommended for this product. The observed molecular weight corresponds to earlier findings in literature (Tanaka et al, Int Immunol. 1998 Sep;10(9):1305-14. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Cynomolgus monkey | Dilution info - | Notes - |
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Target data
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:22265692, PubMed:29212066). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).
Alternative names
FRP, FSTL1, Follistatin-related protein 1, Follistatin-like protein 1
Recommended products
Goat Polyclonal FSTL1/FRP antibody. Suitable for WB and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human FSTL1 aa 250 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FSTL1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q12841
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FSTL1 also known as FRP is a protein that plays an important role in various cellular functions. The protein is a glycoprotein with a molecular mass of approximately 32 kDa and is expressed in a variety of tissues including heart lung and placenta. FSTL1 contains several domains that facilitate its interaction with other proteins and cellular components. It is located both intracellularly and secreted in the extracellular matrix contributing to its role in cell signaling and structural integrity.
- Biological function summary
FSTL1 serves as a modulator in inflammatory and developmental processes. It is a part of a complex that regulates immune responses and cell growth. The protein has been shown to affect the activity of multiple growth factors including Bone Morphogenetic Proteins (BMPs) revealing its regulatory capacity in tissue development and repair. FSTL1 can influence cell differentiation proliferation and survival highlighting its significance in maintaining cellular homeostasis.
- Pathways
FSTL1 has important roles in the regulation of the BMP signaling and Wnt pathways. In the BMP pathway FSTL1 interacts with other signaling molecules to modulate pathway intensity and cellular outcomes. The protein links with BMP proteins to influence processes like bone formation and tissue repair. In the Wnt pathway FSTL1 can modulate key interactions that affect cellular proliferation and development. Through these pathways FSTL1 also relates to proteins such as TGF-beta which participate in various cellular processes.
- Associated diseases and disorders
FSTL1 has relevance in conditions such as rheumatoid arthritis and pulmonary hypertension. The protein shows increased expression in inflammatory environments indicating its involvement in rheumatoid arthritis where it engages with immune response pathways. The connection with pulmonary hypertension also positions FSTL1 as a significant factor in cardiovascular pathologies. In both conditions FSTL1 interacts with cytokines and other immune-related proteins influencing disease progression and response to treatment.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-FSTL1/FRP antibody (ab11805)
Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
All lanes: Western blot - Anti-FSTL1/FRP antibody (ab11805) at 0.5 µg/mL
All lanes: Human Placenta lysate (RIPA buffer, 35µg total protein per lane)
Predicted band size: 35 kDa
Observed band size: 50 kDa
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