AB71548

Anti-FSTL1/FRP antibody

Name: Anti-FSTL1/FRP antibody (ab71548) | Abcam
Brand: Abcam Limited
SKU: AB71548
Price: 480 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(12 Publications)

Rabbit Polyclonal FSTL1/FRP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 12 publications.

View Alternative Names

FRP, FSTL1, Follistatin-related protein 1, Follistatin-like protein 1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 19th February 2018. The following lots is/are still unpurified and still in stock as of 19th February 2018 - GR200980-7, GR200980-9, GR200980-10. Lot numbers other than GR200980-7, GR200980-9, GR200980-10 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Constituents: 2% Sucrose, 1.21% Tris, 0.92% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FSTL1 also known as FRP is a protein that plays an important role in various cellular functions. The protein is a glycoprotein with a molecular mass of approximately 32 kDa and is expressed in a variety of tissues including heart lung and placenta. FSTL1 contains several domains that facilitate its interaction with other proteins and cellular components. It is located both intracellularly and secreted in the extracellular matrix contributing to its role in cell signaling and structural integrity.

Biological function summary

FSTL1 serves as a modulator in inflammatory and developmental processes. It is a part of a complex that regulates immune responses and cell growth. The protein has been shown to affect the activity of multiple growth factors including Bone Morphogenetic Proteins (BMPs) revealing its regulatory capacity in tissue development and repair. FSTL1 can influence cell differentiation proliferation and survival highlighting its significance in maintaining cellular homeostasis.

Pathways

FSTL1 has important roles in the regulation of the BMP signaling and Wnt pathways. In the BMP pathway FSTL1 interacts with other signaling molecules to modulate pathway intensity and cellular outcomes. The protein links with BMP proteins to influence processes like bone formation and tissue repair. In the Wnt pathway FSTL1 can modulate key interactions that affect cellular proliferation and development. Through these pathways FSTL1 also relates to proteins such as TGF-beta which participate in various cellular processes.

FSTL1 has relevance in conditions such as rheumatoid arthritis and pulmonary hypertension. The protein shows increased expression in inflammatory environments indicating its involvement in rheumatoid arthritis where it engages with immune response pathways. The connection with pulmonary hypertension also positions FSTL1 as a significant factor in cardiovascular pathologies. In both conditions FSTL1 interacts with cytokines and other immune-related proteins influencing disease progression and response to treatment.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed : 22265692, PubMed : 29212066). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed : 20054002, PubMed : 22265692).

See full target information FSTL1

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Publications (12)

Recent publications for all applications. Explore the full list and refine your search

Genome medicine 16:98 PubMed39138551

2024

Spatial multiomics reveals a subpopulation of fibroblasts associated with cancer stemness in human hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Si-Yu Jing,Dan Liu,Na Feng,Hui Dong,He-Qi Wang,Xi Yan,Xu-Feng Chen,Min-Cheng Qu,Ping Lin,Bin Yi,Feiling Feng,Lei Chen,Hong-Yang Wang,Hong Li,Yu-Fei He

Oncology reports 50: PubMed37888756

2023

Analysis of the expression and mechanism of follistatin‑like protein 1 in cervical cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Liu,Hong Zhang,Xiaoxia Hu

Nature communications 14:6047 PubMed37770480

2023

Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Shanshan Guo,Yonghao Feng,Xiaopeng Zhu,Xinyi Zhang,Hui Wang,Ruwen Wang,Qiongyue Zhang,Yiming Li,Yan Ren,Xin Gao,Hua Bian,Tiemin Liu,Huanqing Gao,Xingxing Kong

Frontiers in cardiovascular medicine 9:1050310 PubMed36684598

2023

Role of follistatin-like 1 levels and functions in calcific aortic stenosis.

Applications

Unspecified application

Species

Unspecified reactive species

Qianru Zhang,Jiawen Ye,Gan Yang,Ling Yang,Zhongli Chen,Ke Yang,Jia Teng Sun,Yan Liu

Reproduction (Cambridge, England) 163:57-68 PubMed34866594

2021

Follistatin-like I promotes endometriosis by increasing proinflammatory factors and promoting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Sha-Ting Lei,Ming-Qing Li,Yan-Ling Cao,Shu-Hui Hou,Hai-Yan Peng,Dong Zhao,Jing Sun

BMC pulmonary medicine 21:45 PubMed33509151

2021

FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Liu,Jiawei Xu,Tian Liu,Jinxiang Wu,Jiping Zhao,Junfei Wang,Minfang Zou,Lili Cao,Xiaofei Liu,Yun Pan,Siyuan Huang,Liang Dong

Molecular medicine reports 20:5345-5352 PubMed31638229

2019

Downregulation of FSTL‑1 attenuates the inflammation injury during Streptococcus pneumoniae infection by inhibiting the NLRP3 and TLR4/NF‑κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Chen,Zhenshe Liu

Oncology reports 42:2806-2813 PubMed31578589

2019

Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xingang Peng,Peige Wang,Shikuan Li,Yingjun Jiang,Changliang Wu

Oxidative medicine and cellular longevity 2014:294150 PubMed24790701

2014

BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin Va via Erk signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ming Zhang,Min Yang,Li-ping Liu,Wayne Bond Lau,Hai Gao,Man-kun Xin,Li-Xiao Su,Jian Wang,Shu-Juan Cheng,Qian Fan,Jing-Hua Liu

Genes & development 27:1217-22 PubMed23752588

2013

State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.

Applications

Unspecified application

Species

Unspecified reactive species

Gozde Yucel,Banu Altindag,Natalia Gomez-Ospina,Anshul Rana,Georgia Panagiotakos,Maria Fernanda Lara,Ricardo Dolmetsch,Anthony E Oro

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FSTL1/FRP antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (12)

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