Anti-FTSJ2 antibody [2372C6a]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FTSJ2 also known as hPrmA or methyltransferase-like protein 1 is an enzyme with a mass of approximately 83 kDa. It functions as a human 2'-O-methyltransferase and takes part in ribosomal RNA modification by methylating the ribose moiety in RNA molecules. You can find FTSJ2 widely expressed in various human tissues with notable expression in the liver and brain. The enzyme localizes mainly in the nucleolus a site central to ribosomal RNA biosynthesis and modification activities.

Biological function summary

The enzymatic activities of FTSJ2 contribute to ribosome assembly and stability by modifying specific rRNA components. These modifications are essential for the accurate assembly of ribosomal subunits and the proper function of the translation machinery within the cell. FTSJ2 does not function in isolation; it often operates as part of multiprotein complexes which assist in guiding and regulating its methyltransferase activity.

Pathways

Methylation activity by FTSJ2 plays a critical role in the RNA processing pathway and cellular translation machinery. It directly affects the biogenesis of rRNA ensuring the efficient assembly of ribosomal units required for protein synthesis. FTSJ2 interacts with other proteins such as NOP10 and NOP56 which are potentials linking it to the broader ribonucleoprotein complex within cells.

Associated diseases and disorders

Alterations in FTSJ2 activity and expression have connections to several human conditions notably cancer and neurological disorders. Aberrations in the rRNA modification process could lead to disruptions in protein synthesis and uncontrolled cell proliferation which are often observed in cancerous cells. In the context of neurological disorders FTSJ2's function links to proteins like FBL which play key roles in neural cell RNA processing. Changes in their function could potentially contribute to neurodegenerative conditions.