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AB70386

Anti-FTSJD2 antibody

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(2 Publications)

Rabbit Polyclonal FTSJD2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CMTR1.

View Alternative Names

FTSJD2, KIAA0082, MTR1, CMTR1, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, Cap methyltransferase 1, Cap1 2'O-ribose methyltransferase 1, FtsJ methyltransferase domain-containing protein 2, Interferon-stimulated gene 95 kDa protein, MTr1, hMTr1, ISG95

2 Images
Immunoprecipitation - Anti-FTSJD2 antibody (AB70386)
  • IP

Supplier Data

Immunoprecipitation - Anti-FTSJD2 antibody (AB70386)

Detection of human FTSJD2 by immunoprecipitation of whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) from HEK293T cells prepared using NETN lysis buffer.

Lane 1 : Rabbit polyclonal to FTSJD2 (ab70742) at 6 μg per reaction

Lane 2 : Control IgG

Detection : Chemiluminescence with an exposure time of 30 seconds. ab70742 was used at 1 ug/mL for Western blot.

All lanes:

Immunoprecipitation - Anti-FTSJD2 antibody (ab70386)

Predicted band size: 95 kDa

false

Western blot - Anti-FTSJD2 antibody (AB70386)
  • WB

Unknown

Western blot - Anti-FTSJD2 antibody (AB70386)

All lanes:

Western blot - Anti-FTSJD2 antibody (ab70386) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HEK293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Lane 4:

TCMK-1 whole cell lysate at 50 µg

Lane 5:

NIH 3T3 whole cell lysate at 50 µg

Predicted band size: 95 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human CMTR1. The exact immunogen used to generate this antibody is proprietary information.

Q8N1G2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1 mg/mL", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FTSJD2 also known as Fatty Acid Synthase Inhibitor Domain-Containing Protein is a target expressed in a variety of human tissues. This protein has a molecular mass of approximately 60 kDa. The main function of FTSJD2 is to catalyze methylation reactions impacting RNA processing by adding methyl groups to specific adenine residues. This modification affects RNA stability and function playing a direct role in cellular gene expression control.
Biological function summary

The FTSJD2 protein participates in RNA methylation processes and forms part of larger protein complexes involved in RNA modification. These complexes help facilitate accurate and efficient gene expression regulation across different stages of cell growth and division. The participation of FTSJD2 in these complexes emphasizes its role in modulating many cellular activities that depend on RNA methylation.

Pathways

FTSJD2 is an integral player in the RNA modification and stability pathways. These pathways are significant for cellular responses to stress and maintaining genomic integrity. FTSJD2 associates with proteins like METTL3 and ALKBH5 which assist in the dynamic control of RNA methylation. This interaction illustrates the pathway's complexity allowing cellular adaptation and robustness against various stimuli.

FTSJD2 alterations can link to cancers and neurological disorders. In oncology changes in FTSJD2 expression might disrupt normal RNA processes contributing to tumorigenesis. For neurological diseases its role in RNA processing is important for neuron function implicating FTSJD2 dysfunction in disorders like Alzheimer's disease. Studies have shown connections between FTSJD2 and proteins such as FTO in these pathological conditions suggesting avenues for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
See full target information CMTR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

EMBO reports 24:e53408 PubMed37530743

2023

The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma.

Applications

Unspecified application

Species

Unspecified reactive species

Florian Koban,Michael Freissmuth

Cell death & disease 14:245 PubMed37024465

2023

CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3.

Applications

Unspecified application

Species

Unspecified reactive species

A-Bin You,Hu Yang,Chun-Ping Lai,Wen Lei,Lu Yang,Jia-Lin Lin,Shun-Cui Liu,Nan Ding,Feng Ye
View all publications
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