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AB169480

Anti-FUCA2 antibody

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(1 Publication)

Rabbit Polyclonal FUCA2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FUCA2.

View Alternative Names

PSEC0151, UNQ227/PRO260, FUCA2, Plasma alpha-L-fucosidase, Alpha-L-fucoside fucohydrolase 2, Alpha-L-fucosidase 2

1 Images
Western blot - Anti-FUCA2 antibody (AB169480)
  • WB

Unknown

Western blot - Anti-FUCA2 antibody (AB169480)

All lanes:

Western blot - Anti-FUCA2 antibody (ab169480) at 1 µg/mL

Lane 1:

FUCA2 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated at 1/7500 dilution

Predicted band size: 54 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FUCA2.

Q9BTY2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FUCA2 protein also known as plasma alpha-L-fucosidase 2 acts mechanically by hydrolyzing the alpha-16-linked fucose residues from glycoproteins and glycolipids. FUCA2 weighs approximately 53 kDa and localizes mainly to the human liver and blood plasma. Its enzymatic activity helps maintain proper cell surface carbohydrate structures which play important roles in cell-cell communication and adhesion.
Biological function summary

FUCA2 participates in the degradation of fucosylated glycoconjugates. It does not form part of a larger complex; however it operates in concert with other glycosidases to ensure efficient turnover of glycoproteins and glycolipids. This turnover is important in maintaining cellular and systemic homeostasis influencing processes like immune response and inflammatory regulation.

Pathways

FUCA2 is involved in the lysosomal degradation pathway and also interacts within the glycosphingolipid metabolism pathway. It cooperates with proteins like alpha-L-fucosidase 1 (FUCA1) to facilitate the catabolism of glycostructures. These metabolic pathways are essential for recycling cellular materials and processing complex sugar molecules highlighting their role in maintaining cellular efficiency.

FUCA2 presents a connection with fucosidosis and certain cancers such as hepatocellular carcinoma. Its dysfunction can lead to abnormal accumulation of fucosylated compounds contributing to the development of lysosomal storage disorders. In cancer its activity coupled with proteins like alpha-L-fucosidase 3 (FUCA3) may affect the tumor microenvironment influencing cancer cell proliferation and metastasis through altered glycosylation patterns.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
See full target information FUCA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 299:105009 PubMed37406814

2023

An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase.

Applications

Unspecified application

Species

Unspecified reactive species

Ayako Mizuno,Takashi Toyama,Atsuya Ichikawa,Naoko Sakai,Yuya Yoshioka,Yukina Nishito,Renya Toga,Hiroshi Amesaka,Takayuki Kaneko,Kotoko Arisawa,Ryouhei Tsutsumi,Yuichiro Mita,Shun-Ichi Tanaka,Noriko Noguchi,Yoshiro Saito
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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