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AB42124

Anti-Fumonisin antibody [2A2]

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(1 Publication)

Mouse Monoclonal Fumonisin antibody. Suitable for ELISA and reacts with Fusarium verticillioides samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Fumonisin.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2A2

Isotype

IgG1

Light chain type

lambda

Carrier free

No

Reacts with

Fusarium verticillioides

Applications

ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Fusarium verticillioides": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/2000 - 1/10000", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fumonisin particularly fumonisin B1 is a mycotoxin produced by certain Fusarium species notably Fusarium verticillioides. It has a molecular mass around 721 g/mol. This toxic compound is expressed primarily in contaminated agricultural commodities especially maize and maize-based products. Fumonisin acts mechanically by inhibiting the enzyme ceramide synthase which is important in sphingolipid metabolism resulting in accumulation of sphinganine and disruption of cellular processes.
Biological function summary

Sphingolipid metabolism plays an important role in cell membrane integrity and signaling processes. Fumonisin is not part of a multiprotein complex but has a significant impact on sphingolipid biosynthesis pathways. The interruption of these pathways can lead to deregulation of cell growth differentiation and programmed cell death emphasizing the biological role of fumonisin in cell regulation.

Pathways

Ceramide synthase inhibition by fumonisin disrupts the sphingolipid metabolism pathway. This pathway is essential for maintaining cellular homeostasis and is closely related to signaling pathways involving proteins such as serine palmitoyltransferase and sphingomyelin synthase. Fumonisin’s interference in these pathways can affect downstream effects in complex biological systems.

Fumonisin exposure has connections with diseases such as esophageal cancer and neural tube defects. The disruption of sphingolipid metabolism due to interfered ceramide synthase function associates fumonisin with these pathologies. In particular the modulation of proteins like folate receptor and enzymes in folate metabolism may contribute to neural defects while other alterations in cellular mechanisms relate to carcinogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Fumonisin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 8:111161-111175 PubMed29340045

2017

RIP140 and LCoR expression in gastrointestinal cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Mouna Triki,Dorra Ben Ayed-Guerfali,Ines Saguem,Slim Charfi,Lobna Ayedi,Tahia Sellami-Boudawara,Vincent Cavailles,Raja Mokdad-Gargouri
View all publications
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