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AB121411

Anti-FUT11 antibody

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(3 Publications)

Rabbit Polyclonal FUT11 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FUT11 aa 300-500.

View Alternative Names

FUT11, GDP-fucose protein O-fucosyltransferase 4, Fucosyltransferase XI, Galactoside 3-L-fucosyltransferase 11, Fuc-TXI, FucT-XI, Fucosyltransferase 11

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-FUT11 antibody (AB121411)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FUT11 antibody (AB121411)

Immunofluorescent staining of Human cell line A-431 shows positivity in nuclear membrane and golgi apparatus. Recommended concentration of ab121411 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FUT11 antibody (AB121411)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FUT11 antibody (AB121411)

ab121411 at 1/50 dilution staining FUT11 in paraffin-embedded Human liver tissue by Immunohistochemistry.

Western blot - Anti-FUT11 antibody (AB121411)
  • WB

Unknown

Western blot - Anti-FUT11 antibody (AB121411)

All lanes:

Western blot - Anti-FUT11 antibody (ab121411) at 1/250 dilution

Lane 1:

Negative control (vector only transfected HEK293T lysate)

Lane 2:

FUT11-transfected HEK293T over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa))

Predicted band size: 56 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human FUT11 aa 300-500. The exact immunogen used to generate this antibody is proprietary information.

Q495W5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/250 - 1/500", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FUT11 also known as Fucosyltransferase 11 is an enzyme that plays a role in the addition of fucose residues to glycoproteins and glycolipids. The mass of FUT11 typically measures around 47 kDa. It is ubiquitously expressed in various human tissues but higher expression levels are observed in the liver and kidney. FUT11 localizes mainly to the Golgi apparatus where it participates in the modification of substrates involved in cellular recognition and signal transduction processes.
Biological function summary

FUT11 contributes to important cellular mechanisms related to cell-cell adhesion immune response and signaling. As a member of the fucosyltransferase enzyme family it catalyzes the transfer of fucose to N-linked oligosaccharides. This enzymatic action helps to form complex glycoconjugates critical for maintaining cellular functions. FUT11 does not appear to be part of a larger protein complex functioning independently within the glycosylation process.

Pathways

FUT11 is involved in the fucosylation pathway which is a subpathway of glycosylation. This enzymatic process plays a role in creating Lewis antigen structures that are significant in intercellular communications particularly in the immune system. FUT11 interacts with other proteins such as FUT4 and FUT7 which are also part of the fucosylation process impacting the synthesis of these antigens and their downstream effects in cellular signaling and immune responses.

FUT11 is linked to colorectal cancer and congenital disorders of glycosylation. Abnormal FUT11 activity can alter glycosylation patterns promoting tumor progression and metastasis in cancer. In congenital disorders of glycosylation defects in FUT11 may disrupt normal glycan synthesis leading to various developmental and systemic symptoms. In these conditions FUT11 may interact with other glycosyltransferases to exacerbate or mitigate the pathological effects.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (PubMed : 39775168). Attaches fucose through an O-glycosidic linkage (PubMed : 39775168). O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion (PubMed : 39775168). Also shows minor alpha-(1,3)-fucosyltransferase activity toward activity toward biantennary N-glycan acceptors (PubMed : 19088067). However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (PubMed : 19088067).
See full target information FUT11
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:8725 PubMed38622256

2024

Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Mayumi Oishi,Keiko Shinjo,Keisuke Takanari,Ayako Muraoka,Miho M Suzuki,Miki Kanbe,Shinichi Higuchi,Katsumi Ebisawa,Kazunobu Hashikawa,Yuzuru Kamei,Yutaka Kondo

Regenerative therapy 20:41-50 PubMed35402663

2022

YY1-induced lncRNA XIST inhibits cartilage differentiation of BMSCs by binding with TAF15 to stabilizing FUT1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Ying He,Min Cheng,Jia-Lian Ye,Chuan-Hua Peng,Jian Chen,Bin Luo,Xian-Yu Zhang,Qiang Fu

Frontiers in oncology 11:675991 PubMed34221996

2021

Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1.

Applications

Unspecified application

Species

Unspecified reactive species

Wenpeng Cao,Zhirui Zeng,Runsang Pan,Hao Wu,Xiangyan Zhang,Hui Chen,Yingjie Nie,Zijiang Yu,Shan Lei
View all publications
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Product promise

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