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AB169490

Anti-FUT6 antibody

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(1 Publication)

Mouse Polyclonal FUT6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FUT6.

View Alternative Names

FCT3A, FUT6, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6, Fucosyltransferase 6, Fucosyltransferase VI, Galactoside 3-L-fucosyltransferase, Fuc-TVI, FucT-VI

1 Images
Western blot - Anti-FUT6 antibody (AB169490)
  • WB

Unknown

Western blot - Anti-FUT6 antibody (AB169490)

All lanes:

Western blot - Anti-FUT6 antibody (ab169490) at 1 µg/mL

Lane 1:

FUT6 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 42 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FUT6.

P51993

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FUT6 also known as fucosyltransferase 6 is an enzyme with a molecular mass of approximately 45 kDa. This enzyme mechanically transfers fucose a type of sugar to N-glycans found on cell surfaces. FUT6 achieves this through an α13 or α14-glycosidic linkage. Expression of FUT6 occurs mainly in the liver and gastrointestinal tract indicating its role in tissues involved in metabolism and digestion.
Biological function summary

This enzyme plays a role in the biosynthesis of the Lewis blood group antigens which are important for cell-cell interactions. These interactions occur during processes like immune responses and cellular differentiation. FUT6 functions in this context without forming part of larger protein complexes. Its activity directly affects the modification of oligosaccharides to present selectin ligands which facilitates cellular adhesion.

Pathways

FUT6 is an essential player in the fucosylation pathway impacting glycoprotein and glycolipid metabolism. It interacts closely with other members of the fucosyltransferase family such as FUT4 to modulate synthesis of sialyl Lewis x epitopes. These pathways are instrumental in regulating leukocyte extravasation during immune surveillance and inflammation.

FUT6 shows significant relevance to inflammatory diseases and certain types of cancer. Abnormal expression of this enzyme has links to colorectal cancer progression due to altered glycan structures on the cell surface. Additionally FUT6 in connection with other fucosyltransferases like FUT3 relates to inflammatory bowel disease where changes in glycosylation patterns might contribute to pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants (PubMed : 10728707, PubMed : 1339443, PubMed : 1520296, PubMed : 17604274, PubMed : 29593094, PubMed : 7650030, PubMed : 9363434, PubMed : 9451035). Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants (PubMed : 1339443, PubMed : 17604274). Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X (PubMed : 10728707). Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates (PubMed : 1339443, PubMed : 17604274, PubMed : 9363434).. Isoform 2. Does not have alpha(1,3)-fucosyltransferase activity.
See full target information FUT6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BioMed research international 2022:8360481 PubMed36017386

2022

Prognostic Values of BolA Family Member Expression in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Wang,ZhiMing Wang,YiMing Tao
View all publications
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Product promise

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