Anti-FUT8 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FUT8 also known as alpha-(16)-fucosyltransferase represents an important enzyme responsible for transferring fucose from GDP-fucose to the innermost N-acetylglucosamine of N-glycans producing core fucosylation. The molecular mass of FUT8 is approximately 60 kDa. It expresses ubiquitously across various tissues with elevated levels seen in the liver lung and placenta. Researchers frequently study FUT8 due to its significance in glycosylation processes.

Biological function summary

FUT8 impacts numerous cellular activities by modulating glycan branching on glycoproteins. It functions independently and is not directly part of a larger protein complex. FUT8's activity influences cell-cell interactions signaling pathways and receptor functions. It plays an important part in maintaining cellular homeostasis and influences immune responses and cell growth as affected by glycosylation patterns on the cell surface and extracellular matrix.

Pathways

FUT8 is a critical component of the N-glycan biosynthesis pathway where it regulates the addition of fucose to glycans. This process affects protein folding and stability. The enzyme interacts with important glycoproteins like EGFR and integrins impacting signaling pathways such as the Wnt and TGF-beta pathways. Altered FUT8 activity can modify pathways and relationships with other proteins changing cellular responses.

Associated diseases and disorders

FUT8 has connections to cancers and liver fibrosis due to its role in modifying glycans and subsequently influencing cellular communication and adhesion. Abnormal core fucosylation affects proteins like alpha-fetoprotein in liver cancer which might serve as a biomarker. Furthermore changes in FUT8 activity and expression could relate to epidermal growth factor receptor (EGFR) signaling disruptions promoting tumor proliferation. Scientists consider FUT8 a potential therapeutic target in these diseases.