AB150564

Anti-FZD10 antibody

Name: Anti-FZD10 antibody (ab150564) | Abcam
Brand: Abcam Limited
SKU: AB150564
Price: 605 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal FZD10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FZD10.

View Alternative Names

CD350, Frizzled-10, Fz-10, hFz10, FzE7, FZD10

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FZD10 antibody (AB150564)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FZD10 antibody (AB150564)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney, fetal, tissue, labeling FZD10 using ab150564 at 16 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human FZD10. The exact immunogen used to generate this antibody is proprietary information.

Q9ULW2

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "6-16 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Frizzled-10 (FZD10) also known as CD350 is a receptor in the frizzled family of proteins. It acts as a receptor for Wnt signaling proteins typically involved in communications between cells. The receptor belongs to the larger group of G-protein-coupled receptors and contains a seven-transmembrane domain structure. Its molecular mass is about 64 kDa. FZD10 is prominently expressed in various tissues including the brain and certain regions of the gastrointestinal tract with higher expression often seen in fetal tissues compared to adult tissues.

Biological function summary

FZD10 plays a significant role in the Wnt signaling pathway that affects cell development differentiation and proliferation. It usually forms part of a receptor complex that includes other proteins like LRP5/6 and Dishevelled. The interaction of FZD10 with Wnt ligands activates downstream signaling cascades important for embryonic development and maintaining stem cell states. Its involvement in these processes underlines its role in regulating key cellular dynamics.

Pathways

FZD10 is central to both the canonical Wnt/β-catenin pathway and non-canonical Wnt pathways. These pathways orchestrate critical cellular functions such as gene expression cytoskeletal arrangement and cellular movement. FZD10 collaborates closely with other frizzled receptors and Wnt proteins like Wnt3a to modulate these pathways. By regulating the stabilization and localization of β-catenin FZD10 influences various downstream target genes essential for cellular activities.

FZD10 shows association with certain cancers particularly synovial sarcoma and colon cancer. Misregulated expression of FZD10 contributes to oncogenic processes by abnormally activating Wnt signaling pathways which in turn affects cellular proliferation and survival. Additionally its association with Wnt signaling proteins such as β-catenin in these disease states emphasizes its impact on tumorigenesis and progression. Understanding FZD10's role offers potential therapeutic targets for interventions in cancers where this pathway is implicated.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

See full target information FZD10

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Stroke 51:2197-2207 PubMed32486965

2020

Mesenchymal Behavior of the Endothelium Promoted by SMAD6 Downregulation Is Associated With Brain Arteriovenous Malformation Microhemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Weilun Fu,Ran Huo,Zihan Yan,Hongyuan Xu,Hao Li,Yuming Jiao,Linjian Wang,Jiancong Weng,Jie Wang,Shuo Wang,Yong Cao,Jizong Zhao

Journal of the American Heart Association 8:e012746 PubMed31170876

2019

RNA Sequencing Reveals the Activation of Wnt Signaling in Low Flow Rate Brain Arteriovenous Malformations.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Huo,Weilun Fu,Hao Li,Yuming Jiao,Zihan Yan,Linjian Wang,Jie Wang,Shuo Wang,Yong Cao,Jizong Zhao

Gene 668:87-96 PubMed29775757

2018

Molecular characterization of physis tissue by RNA sequencing.

Applications

IHC-P

Species

Human

Christopher R Paradise,Catalina Galeano-Garces,Daniela Galeano-Garces,Amel Dudakovic,Todd A Milbrandt,Daniel B F Saris,Aaron J Krych,Marcel Karperien,Gabriel B Ferguson,Denis Evseenko,Scott M Riester,Andre J van Wijnen,A Noelle Larson

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-FZD10 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FZD10 antibody (AB150564)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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